A new Vis spectrophotometric method was developed for the assay of bisoprolol in pharmaceutical preparations using bromocresol green in hydrochloric acidic medium. The reaction product showed a maximum absorbance at 402 nm proportional with the concentration of bisoprolol. The optimum conditions for the reaction were established. The developed method was validated. The method showed a good line...

Sequential injection lab-at-valve (SI-LAV) micro-solvent extraction determination procedure for tetracycline hydrochloride in pharmaceutical analysis is proposed. It is based on the formation of a yellow colored ion associate of a protonated cation of tetracycline (TCLN) with anionic form of bromocresol green (BCG), in phthalate buffer pH 4, which could be extracted into dichloromethane. The or...

According to statistics, craniocerebral injuries are often the cause of disability among population. The choice medicines for traumatic brain is one most difficult problems in complex treatment such patients. Ademol (1-adamantylethyloxy-3-morpholino-2-propanol hydrochloride) a promising medicinal substance that has huge positive therapeutic effect protective act on damaged and can be presented ...

A simple, accurate and economic spectrophotometric method for the determination of aripiprazole in tablet formulation is proposed. In the present method acidic solution of the aripiprazole formed colored ion-association complexes with bromocresol green, soluble in chloroform. Yellowish orange chromogen showed λ(max) at 414 nm and obeyed Beer's law in the concentration range of 10-60 μg/ml. Stat...

Stimulants of protease-activated receptor-2 (PAR(2)), such as Ser-Leu-Ile-Gly-Arg-Leu-NH(2) (SLIGRL), cause airway smooth muscle relaxation via the release of the bronchodilatory prostanoid prostaglandin E(2) (PGE(2)). The principal aim of the current study was to determine whether compounds that inhibit PGE(2) reuptake by the prostaglandin transporter [bromocresol green and U46619 (9,11-dideox...

     A simple and sensitive extractive spectrophotometric method is described for determination of tropicamide. The method is based on the reaction of tropicamide and bromocresol green. The ion-paired colored complex was extracted with chloroform at pH 3. The extracted complex showed maximum absorbance at 423 nm. The complex was stable up to 2 days and obeyed Beer's law over the concentration r...