Cationic hydride complexes [R-N(1,2-CH(2)CH(2)N=PPh(3))(2)NiH][PF(6)] (R = H, Me) are prepared and shown to react with ethylene to produce NiEt complexes and with LiHBEt(3) in bromobenzene to produce NiPh complexes. These species are also thermolysed at 80 °C to orthometallate one of the phenyl groups of the N=PPh(3) substituents.

The first nickel complex bearing a boryl moiety, (PNP)Ni[B(catechol)](PNP = N[2-P(CHMe(2))(2)-4-methylphenyl](2)(-)), has been prepared, structurally characterized, and analyzed by DFT; this rare species is shown to be a recyclable reagent for the borylation of bromobenzene, via an unusual cycle, by applying the ingredients catecholborane and NaBH(4).

The cis-dihydrocatechol, derived from enzymatic cis-dihydroxylation of bromobenzene using the microorganism Pseudomonas putida UV4, was converted into (-)-epibatidine in eleven steps with complete stereocontrol. In addition, an unprecedented palladium-catalysed disproportionation reaction gave the (+)-enantiomer of an advanced key intermediate employed in a previous synthesis of epibatidine.

Bile Salt Transport after Selective Damage to Acinar Zone 3 Hepatocytes by Bromobenzene in the Rat, GUMUCIO, J. J., KATZ, M. E., MILLER, D. L., BALABAUD, C. P., GREENFIELD, J. M., AND WAGNER, R. M. (1979). Toxicol. Appl. Pharmacol. 50, 77-85. To quantitate the contribution of acinar zone 3 hepatocytes (centrilobular cells) to the transport of physiological concentrations of taurocholate, select...

Seven volatile organic chemicals (VOCs) on the EPA Contaminant Candidate List together with 1,1-dichloropropane were studied for their reaction kinetics and mechanisms with ozone and OH radicals during ozonation and the ozone/ hydrogen peroxide advanced oxidation process (O3/H2O2 AOP) using batch reactors. The three aromatic VOCs demonstrated high reactivity during ozonation and were eliminated...

Baumann & Preusse (1879) and Jaff6 (1879) showed that the mercapturic acids which they isolated from the urine of dogs dosed with bromobenzene or chlorobenzene were formed by the decomposition of acid-labile compounds in the urine, and they believed that these precursors were derivatives of glucuronic acid. This work has recently been revised and extended as a result of the findings of Boyland,...

It has previously been demonstrated that the rate of tumor induction in mice by chemical carcinogens of the hydrocarbon type is retarded by a series of compounds containing labile halogen atoms (9, 10). These halogen compounds ranged from chloro-acetal, a compound of relatively low reactivity, to a variety of highly active acid halides. The velocity constants of their reaction with cysteine und...

background & objectives: the present investigation was designed to evaluate the post-treatment properties of the hydroalcoholic fruit extract of cassia fistula (golden shower tree) in male albino mice. materials & methods: biomarkers and histological liver and kidney alterations, aspartate aminotransferase (ast), alanine aminotransferase (alt), alkaline phosphatase (alp), γ-glutamyl tra...

A facile synthetic route of rivaroxaban has been developed. Using commercially available (R)-epichlorohydrin and bromobenzene as the starting materials, rivaroxaban was obtained in 39% overall yield using a Goldberg coupling as the key step. The synthetic route represents a convenient procedure for the production of rivaroxaban.