Abstract In the current investigation we report an unexpected methyl esterification occurred during coupling reaction of m THPP monoacetic acid 2 with 3-amino-1,2,4-triazole in presence HBTU/DIPEA. The mechanism this was studied, and structure formed ester 5 confirmed by means 1 H, 13 C NMR addition to (MALDI-TOF ESI-HRMS) spectrometry. formation also chemically supported alternative synthetic ...

The peptide nucleic acid backbone Fmoc-AEG-OBn has been synthesized via a scalable and cost-effective route. Ethylenediamine is mono-Boc protected, then alkylated with benzyl bromoacetate. The Boc group is removed and replaced with an Fmoc group. The synthesis was performed starting with 50 g of Boc anhydride to give 31 g of product in 32% overall yield. The Fmoc-protected PNA backbone is a key...

The one-pot three-component reactions of 1-substituted benzimidazoles with ethyl bromoacetate and electron-deficient alkynes, in 1,2-epoxybutane, gave a variety of pyrrolo[1,2-a]quinoxalin-4-ones and pyrrolo[1,2-a]benzimidazoles. The influence of experimental conditions on the course of reaction was investigated. A novel synthetic pathway starting from benzimidazoles unsubstituted at the five m...

Vilsmeier formylation of 2-(1-phenylhydrazonoethyl)naphtho[2,1-b]furan (2) gave 3-naphtho[2,1-b]furan-2-yl-1-phenyl-1H-pyrazole-4-carbaldehyde (3), which was reacted with C- and N-nucleophiles to afford naphthofuranpyrazol derivatives 4-8. Treatment of 2-[(3-(naphtho[2,1-b]furan-2-yl)-1-phenyl-1H-pyrazol-4-yl)methylene]-malononitrile (4a) with reactants having active hydrogen and Et₃N gave the ...

The description of the conformationof sperm whalemetmyoglobin in the crystalline state by Kendrew et al. (2,3) opens the way for correlating information about the crystalline structure with evidence obtained in solution. The reactivity of functional groups in the protein in solution towards various reagents may offer insight as to their availability and hence indicate the degree to which the gr...