A new route for constructing PAHs from cyclohexanone by trimerization, bromination, trisannulation and aromatization, and the synthesis of a novel sulfur-containing polycyclic heteroaromatic have been described.

An unexpected, mild, efficient bromination ring-opening method has been developed for convenient synthesis of various novel biladienes or brominated porphyrins by controlling the amounts of NBS used.

ologically important products proceeds efficiently through the action of enzymes without requiring protection of reactive functional groups. However, only a few studies of synthetic reactions using unprotected (free) amino acids have been reported. Most of the synthetic transformations to natural products, pharmaceuticals, and chiral auxiliaries have been performed with protected amino acids to...

The related red seaweeds Gracilaria sp. from the eastern Mediterranean and Gracilaria chilensis from Chile were similar in their enzymatic inventory for halogenation. In both species, halogenation was dependent upon H(2)O(2) and thus driven by haloperoxidases. These could be inhibited with phosphate and reversibly inhibited with azide and were therefore apparently dependent upon vanadate. Both ...

A recent communication from these laboratories (S. L. Neidleman et al., Tetrahedron Letters 44:5337, 1966) described the bromination and chlorination of the steroidal f3-diketones, 16ketoprogesterone and 16-keto-A-norprogesterone, and the bromination of the steroidal j-ketolactone, 15-keto-1-dehydrotestololactone, by the chloroperoxidase of Caldariomycesfumago (F. S. Brown and L. P. Hager, J. A...