Bromelain is a crude aquaeous extract obtained from both the stem and fruit of the pineapple plant, which contains a number of proteolytic enzymes. The analgesic and anti-inflammatory activities of bromelain were investigated. Bromelain was evaluated for anti-inflammatory effect by carrageen-induced rat paw edema. The analgesic activity was tested by acetic acid-induced writhing response and ho...

BACKGROUND Ananas comosus has long been used for medical purposes. Currently, we are experiencing an unprecedented interest in the use of complementary medicine as well as a growing attention to traditional products such as bromelain for wound healing and reducing pain. OBJECTIVES The aim of this study was to determine the effect of oral bromelain on perineal pain and wound healing after epis...

Bromelain is an extract obtained from the pineapple plant and is used as a traditional folk remedy for several ailments. In this review, a comprehensive electronic database search was carried out to compile available literature on therapeutic implications of bromelain. Pharmaceutical value of bromelain has been demonstrated in different surgical sub-specialties. Diverse biological processes lik...

BACKGROUND Microglial cells act as the sentinel of the central nervous system .They are involved in neuroprotection but are highly implicated in neurodegeneration of the aging brain. When over-activated, microglia release pro-inflammatory factors, such as nitric oxide (NO) and cytokines, which are critical in eliciting neuroinflammatory responses associated with neurodegenerative diseases. This...

UNLABELLED Bromelain, an enzyme extracted from the stem of the pineapple plant has been proposed as a treatment for reducing pain and swelling following acute muscle injuries but studies are yet to be done on its effect on tendon healing. This study therefore investigated the effects of bromelain on tenocyte proliferation and the tendon malondialdehyde (MDA) level in the early stage of healing ...

Bromelain is a concoction of sulfhydryl proteolytic enzymes. Depending upon the site of extraction it can be regarded as either stem bromelain (SBM) (EC 3.4.22.32) or fruit bromelain (FBM) (EC 3.4.22.33). Bromelain remain enzymatic active over a broad spectrumand endure a range of pH (5.5 to 8.0) and temperature (35.5 to 71 oC). It is one of the extensively investigated proteolytic enzyme owing...

microglia, the sentries of the brain, is highly implicated in neurodegeneration as in neuroprotection. chronic microglial activation endangers neuronal survival through the release of various potentially neurotoxic mediators including nitric oxide (no). thus, negative regulators of microglial activation have been considered as potential therapeutic candidates to target neurodegeneration, such a...

AIMS AND OBJECTIVES To evaluate the effect of bromelain on pain and swelling after surgical removal of third molars. MATERIALS AND METHODS A prospective randomized clinical study was conducted among 40 patients requiring surgical removal of impacted mandibular third molars. All the impacted molars were surgically removed, and the patients were administered bromelain along with amoxicillin. Pa...

Brazil produces over than 70,000 ha of pineapple, being the world leader in pineapple production, and Minas Gerais State alone produces over than 600 kt/y. The pineapple is the marketable plant part, which represents only 23 % of the plant itself, and the remaining plant, stem, leaves, bark and crown, being considered an agroindustrial residue. This residue contains great amount of bromelain, a...