Introduction/Objective. Somatosensory evoked potentials are a neurophysiological tool for testing the effects of drugs in humans and animals. The aim this study was to estimate way that bromazepam ibuprofen had on tooth pulp-evoked (TPEPs) after non-painful stimuli, as well detect possible differences activity. Methods. Sixty young healthy subjects were included study. They arranged into three ...

abstract: In this paper we describe the thin layer chromatographic separation of eight of the most frequently used benzodiazepine derivates (alprazolam, bromazepam, chlorazepate potassium, chlordiazepoxide, diazepam, nitrazepam, oxazepam) and their degradation products after acid hydrolysis. Our aim was not only to develop a simple, rapid and efficient method for their separation but also the o...

Benzodiazepines (BZDs) are one of the most important drugs that have been used in treatment neuropsychological disorders. Indeed, BZDs abused by drug addicts regardless their therapeutic uses. Therefore, it was forensic and clinical toxicology to reach an easy reliable method for screening quantification human plasma matrix. In current work, five BZDs, namely bromazepam, clonazepam, lorazepam, ...

A total of 588 blood specimens collected in an emergency unit were screened for benzodiazepines (BZDs) using enzyme-multiplied immunoassay and gas chromatography. Two-hundred eighty-five samples were positive for BZDs, and 303 samples that were negative by EMIT included 20 samples with BZDs detectable by gas-liquid chromatography. A total of 15 BZDs were identified, and the most frequently occu...

The concentrations of free fatty acids in plasma were estimated in thirty-three subjects, before and after (24 hours and 72 hours) the start of bromazepam oral administration in a daily dose of 6 mg (1.5 mg at 7 a.m., 1.5 mg at 3 p.m. and 3 mg at 11 p.m.). A fourth estimation was performed 72 hours after drug discontinuation. A control group of twelve subjects received a placebo according to th...

pharmaceuticals are considered to be important environmental contaminants. the aim of this study was to evaluate their presence in water intended for public supply to municipally of rio de janeiro, brazil. the regional environmental assessment was done from the analysis of surface water and distribution for the presence of psychiatric drugs. the study reveals the presence of benzodiazepine deri...

The prescriptions of all patients who attended an urban general practice from September 1987 to December 1987 were studied. Of the 111 patients (60 females and 51 males) who received a psychotropic prescription the commonest presenting complaint was insomnia (56 patients or 50.5%). This was followed by tension, headache and unexplained aches and pains (19 patients or 17.1%), and anxiety (nine p...