OBJECTIVE Our goal was to investigate, in a large population of women with ductal carcinoma in situ (DCIS) and long follow-up, the relationship between margin width and recurrence, controlling for other characteristics. BACKGROUND Although DCIS has minimal mortality, recurrence rates after breast-conserving surgery are significant, and half are invasive. Positive margins are associated with i...

With a population in which 70% of the patients were overweight or obese, we reviewed retrospectively 135 breasts of 70 consecutive patients who underwent implant-based immediate breast reconstruction using freeze-dried AlloDerm as the acellular dermal matrix. Several obesity-related parameters were evaluated to determine their possible correlation to early postoperative complications. We found ...

Despite the results of the National Surgical Adjuvant Breast and Bowel Project B-17, there continues to be debate regarding the most appropriate treatment for patients with ductal carcinoma in situ (DCIS) of the breast. Numerous clinical, pathologic, and laboratory factors can aid clinicians and patients wrestling with the difficult treatment decision-making process. Our research has shown that...

BACKGROUND Determination of the hematological indices is a useful prognostic laboratory investigation in the cancer research. The neutrophil to lymphocyte ratio (LNR), red cell distribution width (RDW) and the platelet distribution width (PDW) are useful markers for the prediction and the prognosis of breast cancer. The aims of this study were to assess the hematological indices in breast cance...

1 High frequencies of polyfunctional CD8 NK cells in 1 chronic HIV-1 infection are associated with slower 2 disease progression 3 4 Fareed Ahmad, Henoch S. Hong, Marc Jäckel, Alexandra Jablonka, I-Na Lu, 5 Nupur Bhatnagar, Johanna M. Eberhard, Benjamin A. Bollmann, Matthias Ballmaier, 6 Margot Zielinska-Skowronek, Reinhold E. Schmidt and Dirk Meyer-Olson 7 8 Klinik für Immunologie und Rheumatol...

The growing use of simulation for military training, systems analysis, acquisition, and command decision aiding has created a need to develop accurate computational models of human and organizational behavior. While the use of Human Behavior Representations (HBRs) has increased rapidly over the last decade, significantly greater acceptance within the user community would occur if better user-or...

Human eosinophil derived neurotoxin (EDN), a granule protein secreted by activated eosinophils, is a biomarker for asthma in children. EDN belongs to the human RNase A superfamily possessing both ribonucleolytic and antiviral activities. EDN interacts with heparin oligosaccharides and heparin sulfate proteoglycans on bronchial epithelial Beas-2B cells. In this study, we demonstrate that the bin...

Published research indicated that a line (FL) of turkeys selected for increased shank width and exhibiting good walking ability (WA) and improved leg structure was useful in improving WA of a cross with an unimproved commercial sire line while remaining competitive in BW and body conformation. The purpose of the present study was to determine whether the FL line was useful in improving WA of tw...

background : breast cancer is a complicated disease and has various clinical manifestations and prognosis. the aim of this study is to make a breast cancer model suitable for basic, preclinical and clinical studies. materials and methods: five virgin bulb/c mice aged 6 weeks and spontaneous murine mammary adenocarcinoma cells (mmac) were used. after anesthesia induction, 1-3 million of mmacs we...

Adequate surgical margins in breast-conserving surgery are an important predictor of local recurrence (LR) rates. The definition of tumor-free margins in National Surgical Adjuvant Breast and Bowel Project (NSABP) trials requires that tumor cells do not touch ink, but subsequent retrospective single-institution studies have suggested that wider margins confer greater protection against LR. Part...