Triple-negative breast cancers (TNBC),which include the basallike and claudin-low disease subtypes, are aggressive malignancies for which effective therapeutic targets are lacking. NF-kB activation has an established role in breast malignancy, and it is higher in TNBC than other breast cancer subtypes. On this basis, we hypothesized that proteins derived from NF-kB target genes might be molecul...

background : breast cancer is one of the most frequent malignancies among iranian women. triple-negative breast cancer (tnbc) is referred to a type of breast cancer which three biomarkers of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (her2), are negative. materials and methods: in this case control study, immunohistopathologic data of patients with tn...

background: women's role in family and their participation in social, economical and cultural activities make them a part of development process. paying attention to women's health is a social investment. nowadays 70% of women suffer from breast pain and two third of these pains are periodical. among the pain killing methods, herbal medicine is more compatible with human body and has fewer side...

background: inflammatory breast cancer (ibc), a subgroup of locally advanced breast cancer (labc), is diagnosed based on clinical findings, and seems to be different from other types of labc. the purpose of this study was to compare clinicopathological characteristics and outcomes between inflammatory and non-inflammatory labc patients at breast cancer research center (bcrc), tehran, iran. meth...

background: breast cancer is third order malignancy in women among other malignancies.   various studies showed that incidence of breast cancer can be lower down by early detection of breast cancer. mammographic screening is considered more effective modality in detecting early stage breast cancer in women who are at elevated risk for breast cancer. the aim of this study is to report the result...

background: we studied the patterns of premenopausal and postmenopausal breast cancer incidence and its established risk factors in iran in 2010. in addition, we estimated the 5-year prevalence of breast cancer in the country. methods: we performed an internet and library literature review. we used national cancer registry data, demographic health surveys, national censuses and world bank data ...

breast cancer is the most common cancer occurring among women. the mortality rate of breast cancer can be reduced by regular breast cancer screening program. this study was carried out to identify the knowledge and practice of women about breast cancer screening in zahedan, southeast of iran. in this cross- sectional study, 384 women were selected as an improbability sample of women referring t...

conclusion st-vab and mgl-eb are reliable biopsy methods for microcalcifications. in proper indications, breast microcalcifications could be obtained by each method without missing diagnosis of breast cancer. objectives to evaluate the outcome of st-vab and mammography-guided localization and excisional biopsy (mgl-eb) for microcalcifications. patients and methods two radiologists retrospective...

breast reconstruction (br) surgery is not common for the treatment of breast cancer in low- and middle-income countries, including iran. we evaluated the quality of life (qol) in iranian breast cancer patients who underwent br at the cancer institute of iran. we compared patients who had br with breast cancer patients who had a radical mastectomy as the control group, matched for age, and time ...

absract idiopathic granulomatous mastitis is a rare, inflammatory, and benign breast disease characterized by non-caseating granulomata and microabscesses limited to breast lobules. this condition presents as a firm breast mass that is clinically and radiologically indistinguishable from breast cancer, or as multiple or recurrent abscesses, or mastitis in a young non-lactating woman. almost alw...