BACKGROUND After focused high dose radiotherapy of brain metastases, differentiation between tumor recurrence and radiation-induced lesions by conventional MRI is challenging. This study investigates the usefulness of dynamic O-(2-18F-Fluoroethyl)-L-Tyrosine positron emission tomography (18F-FET PET) in patients with MRI-based suspicion of tumor recurrence after focused high dose radiotherapy o...

Abstract A major factor that contributes to the unchecked growth and recurrence of glioblastoma (GBM) tumors is presence a heterogeneous population GBM stem-like cells (GSCs) continuously replenish tumor mass. Targeting strategies against this key cell have rarely considered trophic signals from peritumoral neural cells, which can protect during therapy therefore promote recurrence. Here, we fo...

Gliomas are the most common type of brain tumor in the central nervous system of adults, and are highly aggressive, resistant to treatment, and prone to recurrence. Brain tumor stem cells (BTSCs) are implicated in tumor initiation and recurrence. Cluster of differentiation (CD)133 is currently the most widely used BTSC marker; however, its role in glioma development and progression is largely u...

Pilocytic astrocytoma (PA) is a low grade benign tumor, commonly occurs in Cerebellum (42-60%), Optic & hypothalamic region (9-30%), Brain Stem (9%). They rarely spread. It within the ventricle. In this report, we described our experience with cranial pilocytic 14-year-old child, who initially treated near total decompression of tumor. Four and half years later, recurrence primary tumor obs...

Breast cancer is among the most common malignancies that metastasize to the brain, with 15% to 20% of patients with metastatic breast cancer eventually developing brain metastases. We previously reported a method to enumerate tumor cells in the cerebrospinal fluid (CSF) of patients with breast cancer with central nervous system (CNS) metastases, a setting that lacks sufficiently informative bio...

One of the unusual variant of ovarian tumor is sex cord stromal tumor with annular tubules (SCTAT). The recurrence in case of malignant ovarian SCTAT ranges from 3mo to 20yr. This report describes the case of recurrence of SCTAT in a 35yr old woman after 4yr of hysterectomy with bilateral salphingo-Oopherectomy. Microscopic examination revealed features of SCTAT. Because of its unusual behavior...

Background. Breast cancer contributed to 11.8 % of all the oncological diseases detected in Russia 2020 and 21.7 tumors among women. The frequency brain metastases is estimated at 13–32 %. It known that HER2 positive triple negative breast cancers metastasize more frequently. Aim. To present case stereotactic high‑dose irradiation for a large brainstem metastasis from re‑irradiation recurrence....

Rhabdoid papillary meningioma is an uncommon aggressive variant of meningioma which has the potential to metastasize and spread throughout the brain and even out of the cranium. Herein, we present recurrence of the brain tumor in a 26-year-old woman. The patient had history of the surgery for two lesions in the right temporal lobe and the left cerebellopontine angle. Imaging showed three lesion...

Preventing tumor recurrence after surgical resection of a brain tumor is a significant clinical challenge because current methods deliver chemotherapeutic agents in a rapid manner and are not effective against the residual tumor cells. To overcome this drawback, we report a simple method to prepare magnetic resonance imaging (MRI) traceable ultra-thermosensitive hydrogels with rapid gelation ab...