نتایج جستجو برای: brain toxicity
تعداد نتایج: 585041 فیلتر نتایج به سال:
This study was performed to evaluate the effect of feeding with Oregano Vulgare essential oil supplementation on the brain tissue of Koi fish under long-term exposure to naproxen. For this purpose, 135 Koi fish (Mean weight: 1.5 gr; Average length: 6±1 cm) were divided into three groups with three replications. These fish were fed with two diets including a basic diet (BD) and an essential oil ...
Flavone analogs are natural compounds of the flavonoid class that have a wide range biological activities. The present study aimed to predict, with aid in silico methodologies, oral bioavailability and pharmacokinetic toxicological analyzes for three flavone analogues (apigenin, chrysin luteonlin). revealed good availability, favorable parameters. Virtual Screening performed predict all did not...
Modulation of thiol levels may alter both the efficacy and toxicity of chemotherapeutic agents. We investigated cytoenhancement, using L-buthionine-[S,R]-sulfoximine (BSO) to reduce cellular glutathione levels prior to intracarotid alkylator administration. We also evaluated chemoprotection against chemotherapy-induced systemic toxicity when the thiol agents N-acetylcysteine (NAC) and sodium th...
Background: Studies showed thyroid hormones influence proliferation of cancer cells. The main aim of this study was to investigate the effects of cytotoxic thyroid hormone T4 on proliferation of brain glioblastoma cells (A172) in cell culture. Methods: In this laboratory experimental study, A172 cells were randomly divided into control group and groups exposed to doses 0.1, 0.5, 1, 5, 10, 20, ...
Monosodium glutamate is a sodium salt of a nonessential amino acid, L-glutamic acid, which is widely used in food industry. Glutamate plays an important role in principal brain functions including formation and stabilization of synapses, memory, cognition, learning, as well as cellular metabolism. However, ingestion of foodstuffs rich in monosodium glutamate can result in the outbreak of severa...
brain injury associated with methanol toxicity can be ischemic, necrotic or hemorrhagic in nature. it most commonly affects the putamenal area bilaterally, but can be seen in other locations. this report describes a 22-year-old intoxicated patient who developed an epidural hematoma following hemodialysis. heparinization during hemodialysis may contribute to cerebral hemorrhagic complications in...
Manganese (Mn) is a required element and a metabolic byproduct of the contrast agent mangafodipir trisodium (MnDPDP). The Mn released from MnDPDP is initially sequestered by the liver for first-pass elimination, which allows an enhanced contrast for diagnostic imaging. The administration of intravenous Mn impacts its homeostatic balance in the human body and can lead to toxicity. Human Mn defic...
Alpha-cypermethrin (?-CP) a synthetic pyrethroid (type-II) insecticide, dissolved in dimethyl sulfoxide (DMSO-1ml) given consecutive daily orally for 60 days at 1/10LD50 (14.5mg/kg). The animals were sacrificed on day 61st. Biochemicals, cytochromeP450, b5 contents in liver along with antioxidant status, tissue residual concentration, and brain GABA level were studied. It increased the serum am...
Abstract AIMS Selected patients with multiple brain metastases can benefit from stereotactic radiosurgery (SRS). Brain V12 (total volume receiving 12Gy including target) predict for late toxicity in single target benign disease, however their value remains uncertain metastases. We report the incidence and evaluate predictors of 4 or more treated fraction SRS. METHOD 226 2160 2014-21 were retros...
Background: We earlier reported that datumetine possesses binding affinity with NMDAR and that 14-day exposure to datumetine altered NMDAR signalling by mimicking glutamate toxicity. Here, we investigated the potential neuroprotective effect of a single shot of a low dose of datumetine administration in BALB/c mice. Results: Relative to Veh, datumetine downregulate the expression of CamKIIα i...
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