UNLABELLED The efficacy of cerebral arterial bypass surgery was assessed on brain perfusion SPECT using statistical parametric mapping (SPM) and a probabilistic brain atlas. METHODS Fifteen patients with ischemia in the internal carotid artery (ICA) territory and 21 age-matched healthy volunteers were enrolled. (99m)Tc-HMPAO basal/acetazolamide brain perfusion SPECT was performed 2 wk before ...

For insulin to act within the brain, it is primarily transported from blood across blood-brain barrier (BBB). However, endocytic machinery necessary for delivering brain remains unknown. Additionally, there are processes endothelial cell that designed respond binding and elicit intracellular signaling. Using pharmacological inhibitors of different types endocytosis (clathrin-vs. caveolin-mediat...

Background Facilitation of venous outflow from the brain is largely believed to be responsible for beneficial effect head elevation on intracranial pressure (ICP). However, impact cerebral perfusion can deleterious. Although adverse obstructing in setting hypertension well documented, converse (improvement with augmented drainage) has not been demonstrated. Our hypothesis that active augmentati...

BACKGROUND Patients with aluminum hydroxide adjuvant-induced macrophagic myofasciitis (MMF) complain of arthromyalgias, chronic fatigue and cognitive deficits. This study aimed to characterize brain perfusion in these patients. METHODS Brain perfusion SPECT was performed in 76 consecutive patients (aged 49±10 y) followed in the Garches-Necker-Mondor-Hendaye reference center for rare neuromusc...

OBJECTIVE Cerebral perfusion pressure<40 mm Hg following pediatric traumatic brain injury has been associated with increased mortality independent of age, and current guidelines recommend maintaining cerebral perfusion pressure between 40 mm Hg-60 mm Hg. Although adult traumatic brain injury studies have observed an increased risk of complications associated with targeting a cerebral perfusion ...

BACKGROUND AND PURPOSE Both the existence and clinical relevance of a steal phenomenon in brain arteriovenous malformations (AVMs) remains a matter of debate. This study aimed to assess perfusion in the brain adjacent to brain AVMs and to relate these to macrovascular blood flow in a single measurement. MATERIALS AND METHODS Twenty consecutive patients with AVMs with a median age of 37 years ...