Dementia is a growing global health concern, with significant social and economic implications. As the search for preventive strategies intensifies, recent studies have investigated potential association between oral health, particularly flossing, risk of developing dementia. This review aims to critically analyze existing evidence explore mechanisms underlying relationship flossing Various bee...

The aim of this study was to examine the anti-inflammatory effects of co-administration of growthhormone-releasing peptide-2 (GHRP-2) and growth hormone (GH) on tumor necrosis factor-α (TNF-α),interleukin-6 (IL-6) and inducible nitric oxide synthase (iNOS) gene expression induced by LPS in the mousebrain. Thirty-five male NMRI mice (25±5 g) were injected through the mouse tail vein with saline,...

Traumatic brain injury (TBI) is defined as an external mechanical injury to the brain. Neuroinflammation plays a vital role in the pathophysiology of TBI. Microglia and astrocytes play a central role in the initiation and regulation of inflammation. Numerous pro-inflammatory mediators including cytokines, chemokines, reactive oxygen species (ROS) and nitric oxide (NO) released by microglia. In ...

Novel coronavirus causes the outbreak of COVID-19. There is still no verified treatment regimen against this novel virus; however, different drugs and compounds have been tested against it. Ample proposals have led to a good understanding of pathogenesis and drug efficacy against the novel virus disease. Excess systemic inflammation, which is described as cytokine storm, in the severe cases of ...

background and objectives: many nepeta species have been commonly used in iranian folk medicine as tranquilizer, relaxant, carminative and restorative tonic for nervous and respiratory disorders. inflammation is a problem in many diseases and has an important role in brain function that can cause neurodegenerative disorders. inflamed glial cells can exacerbate neurodegenerative diseases by prod...