Alzheimer’s disease (AD) is a neurodegenerative brain disorder which has no effective treatment yet due to the blood barrier in the brain that limits the drugs with the potential of disease improvement. Extracellular vesicles (EVs) are biocompatible nanoparticles with a lipid membrane. These vesicles are secreted from various cells such as mesenchymal stem cells (MSCs) and can pass through biol...

Alzheimer’s disease (AD) is a neurodegenerative brain disorder which has no effective treatment yet due to the blood barrier in the brain that limits the drugs with the potential of disease improvement. Extracellular vesicles (EVs) are biocompatible nanoparticles with a lipid membrane. These vesicles are secreted from various cells such as mesenchymal stem cells (MSCs) and can pass through biol...

Background: Early diagnosis of patients in the early stages of Alzheimer's, known as mild cognitive impairment, is of great importance in the treatment of this disease. If a patient can be diagnosed at this stage, it is possible to treat or delay Alzheimer's disease. Resting-state functional magnetic resonance imaging (fMRI) is very common in the process of diagnosing Alzheimer's disease. In th...

a biopsy diagnosed patient with creut7,{eldt-jacob diseaseis reportedin. iran. this 53~year-old hunte'r,esented  n may 1994 to mehr hospital with typica clinical manifestations of creunfeldi-jacob disease and died 4 months later. brain biopsy revealed severe neuronal loss, spongiosis and gliosis oj cerebral cortex. e;xposureofthis hunter to the brain tissue ofanimals may explain the route of tr...

catecholamine is a group of neurotransmitters that is believed to be responsible for the normal function of animal brain. physiological and behavioral changes of human body have been reported due to the damage of the brain function following lead exposure. due to the assumption of lead disposal in brain tissue with two year for its half-life, which results in alteration of brain function, we in...

Introduction: Alzheimer’s disease is a progressive neurodegenerative disorder, characterized by impairment of memory and changes in behavior and personality. Recent evidence suggests that mitochondrial channels play important roles in memory disorders. Accordingly, the biophysical properties of a single potassium channel were investigated in the brain mitochondrial inner membrane of rat with...

In a mouse model of Alzheimer’s disease, interleukin-3 protein released by cells called astrocytes activates microglia, the immune brain. These then cluster around disease-associated aggregates and help to clear them. An immune-signalling axis in brain helps reduce plaques.