background: the rodent somatosensory barrel cortex is an ideal model to examine the effect of experience-dependent plasticity on developing brain circuitry. sensory deprivation such as whisker deprivation may affect neuroanatomical aspects of the brain during developmental processes. the present study designed to investigate the possible effects of whisker deprivation on the morphometric charac...

posttraumatic stress disorder (ptsd) is a disorder of emotional and mental stress occurring as an outcome of injury or severe emotional shock. several neuroimaging studies in humans have shown the functions and relationship between the anatomical changes of brain and ptsd. the three major areas of the brain are affected by ptsd .these three areas are the amygdala, hippocampus and prefrontal cor...

Objective: Phantom limb pain (PLP) as neuropathic pain affects the life of amputees. It is believed an efficient PLP treatment should consider the underlying neurological mechanisms. Hereby, we investigated brain activity in PLP’s and relations to the psychological and cognitive dimension of chronic pain. We investigate differences in resting brain activities between amputees with and without p...

the variations of glucose 6-phosphate dehydrogenase (g6pd) activity in different brain regions of normal, hypo- and hyperthyroid rats were investigated. hypo- and hyperthyrodism were experimentaly induced by administration of methimazol and liothyronine, respectively. in normal rats, midbrain had the minimum (70 mu/mg) and cerebral cortex the maximum (349 mu/mg) g6pd activity. hyperthyrodism in...

aim: oxidative stress plays a crucial role in the pathophysiology of ischemic stroke. since water-solublefullerene derivatives act as the potent scavenger of oxygen free radicals in biological systems, we aimedto investigate the possible protective effects of fullerol nanoparticles on brain infarction and edema intransient model of focal cerebral ischemia in rat.materials & methods: experiment ...

a biopsy diagnosed patient with creut7,{eldt-jacob diseaseis reportedin. iran. this 53~year-old hunte'r,esented  n may 1994 to mehr hospital with typica clinical manifestations of creunfeldi-jacob disease and died 4 months later. brain biopsy revealed severe neuronal loss, spongiosis and gliosis oj cerebral cortex. e;xposureofthis hunter to the brain tissue ofanimals may explain the route of tr...

The analysis of evoked potentials of sensorimotor cortex in response to electrical stimulation of n. ischiadicus shows that the extremal factor hypokinesia has a negative impact on the dynamics of formation of amplitudal and temporal characteristics since eyes openning in 2-weeks old rats. The most vulnerable process to the impact of hypokinesia is the first-positive phase, which disappears in ...

glial cell line-derived neurotrophic factor (gdnf) plays important roles not only for the differentiation of neurons during normal development but also for the survival and recovery of many populations of mature neurons. the effect of traumatic brain injury (tbi) on the expression of gdnf is currently unknown. to determine if there is alteration in gdnf after tbi we examined the effect of contr...

objective(s):melatonin is known as an anti-inflammatory agent, and it has been proven to exert neuroprotection through inhibition of cell death (apoptosis) in several models of brain injury.secondary injury following the primary traumatic brain injury (tbi) results in glial cells activation, especially astrocytes. in fact, astrocyte activation causes the production of pro-inflammatory cytokines...

Low frequency stimulation (LFS) is a potential alternative therapy for epilepsy. However, it seems that the anticonvulsant effects of LFS depend on its target sites in the brain. Thus, the present study was designed to compare the anticonvulsant effects of LFS administered to amygdala, piriform cortex and substantia nigra on amygdala kindling acquisition. In control group, rats were kindled in ...