The overall disposition and hepatobiliary transport of BQ-123, an anionic cyclopentapeptide, and three analogs were examined in rats in vivo. Total body clearance (CLtotal) and biliary excretion clearance (CLbile, p) exhibited 4- to 8-fold differences between the compounds, with those for BQ-485 and compound A having the highest and lowest values, respectively. The CLbile, p values of BQ-485, B...

Eight Na-repleted volunteers underwent 3 separate 90-minute infusions of either N(G)-nitro-L-arginine methyl ester (L-NAME) 3.0 mg. kg(-1). min(-1) or endothelin-A receptor (ET-A) blocker BQ-123 (BQ) 0.125 nmol. kg(-1). min(-1) or both. Mean arterial pressure (MAP), glomerular filtration rate (GFR), renal blood flow (RBF), renal vascular resistances (RVR), and sodium excretion rate (UNaV) were ...

Binding and functional studies were conducted to elucidate the receptor subtypes mediating contractions of human bronchus induced by endothelin (ET) receptor ligands. Binding experiments in human bronchial smooth muscle membrane preparations revealed the presence of ETA and ETB receptors in the ratio of approximately 40:60. In the presence of the combination of 1 microM BQ-123 (ETA receptor ant...

Electrophile-mediated post-translational modifications (PTMs) are known to cause tissue toxicities and disease progression. These effects are mediated via site-specific modifications and structural disruptions associated with such modifications. 1,4-Benzoquinone (BQ) and its quinone-thioether metabolites are electrophiles that elicit their toxicity via protein arylation and the generation of re...

Bq−Bq mixing with q = d or q = s is governed byM −iΓ/2 with the hermitian 2×2 matrices M q and Γ. The (1, 2) element of M q − iΓ/2 induces Bq → Bq transitions. The mass matrix element M q 12 stems from the dispersive part of the box diagram in Fig. 1, which is obtained from the full diagram by replacing the loop integral with its real part. The decay matrix element Γq12 is calculated from the a...

Here we present the first report of a carbon-γ-Fe₂O₃ nanoparticle composite of mesoporous carbon, bearing COOH- and phenolic OH- functional groups on its surface, a remarkable and magnetically separable adsorbent, for the radioactive material emitted by the Fukushima Daiichi nuclear power plant accident. Contaminated water and soil at a level of 1,739 Bq kg(-1) ((134)Cs and (137)Cs at 509 Bq kg...

Based on past studies of an experimental model of severe intrauterine pulmonary hypertension, we hypothesized that endothelin-1 (ET-1) contributes to high pulmonary vascular resistance (PVR), hypertensive lung structural changes, and right ventricular hypertrophy (RVH) caused by prolonged closure of the ductus arteriosus. To test this hypothesis, we studied the effects of BQ 123, a selective ET...

BACKGROUND Endothelin (ET) is implicated in the pathophysiology of chronic renal failure (CRF). We therefore studied the systemic and renal hemodynamic effects of ET receptor antagonists in CRF and examined differences between selective ETA, selective ETB, and combined ETA/B receptor blockade. METHODS AND RESULTS We conducted a randomized, placebo-controlled, double-blind, 4-way crossover stu...

In a recent work [FR], Frenkel and Reshetikhin developed the theory of q-vertex operators. They showed that n-point correlation functions associated to q-vertex operators satisfy a qdifference equation called q-deformed Kniznik-Zamolodchikov equation. In the derivation of this equation, a crucial point is that the quantum affine algebra is a quasi-triangular Hopf algebra. By using several prope...

Endothelin (ET)-1 is one of the most potent agonists of airway smooth muscle and can act via two different ET receptor subtypes, i.e., ETA and ETB. To determine the effects of ET-1 on in vivo pulmonary function and which ET receptors are involved in murine lungs, we investigated 1) the effects of ET and sarafotoxin S6c (S6c), a selective ETB agonist, on pulmonary function and 2) the effects of ...