Transcriptional regulation by hormonal 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)] involves occupancy of vitamin D response elements (VDREs) by the VDRE binding protein (VDRE-BP) or 1,25(OH)(2)D(3)-bound vitamin D receptor (VDR). This relationship is disrupted by elevated VDRE-BP, causing a form of hereditary vitamin D-resistant rickets (HVDRR). DNA array analysis showed that of 114 genes regu...

Background: Tibolone is frequently used as a hormone-like alternative to traditional HRT. Therefore, it is valuable to compare the effects of tibolone and HRT on cardiovascular diseases risk factors. Methods: A total of 156 healthy non-surgical postmenopausal women were included in an open randomized study. They were assigned to receive daily 2.5 mg tibolone plus one Cal+D (500 mg calcium and 2...

the activity of angiotension converting enzyme (ace; omim: 106180) in different brain regions of patients with schizophrenia changed, suggesting a possible involvement of ace in psychiatric disorders. genetic polymorphism of insertion/deletion (i/d; dbsnp rs4646994) in the gene encoding ace has been well defined.the present case-control study was performed on 363 (268 males, 95 females) in-pati...

We characterized sequences of a novel SSS139 RsaI satellite DNA family in Drosophila gouveai and Drosophila seriema, two members of the Drosophila buzzatii cluster (D. repleta group). The sequences were AT-rich (69%) with a monomer unit length of about 139 bp and contained two direct subrepeats of 14 bp and 16 bp, suggesting that it might have originated by the duplication of smaller sequences....

BACKGROUND Metabolic syndrome (MeS) is being recognized as a risk factor for insulin resistance and cardiovascular disease. The present study was aimed to find out the possible association between 45-bp I/D polymorphism of uncoupling protein 2 (UCP2) and MeS. METHODS DNA was extracted from peripheral blood of 151 subjects with and 149 subjects without MeS. 45-bp I/D variant of UCP2 was detect...

where S is the Landweber-Novikov algebra. S has the added advantage of being a cocommutative Hopf algebra over Z. This paper does not remove this difficulty, but we will show that the monoid of multiplicative operations in BP*BP, (i.e. those operations which induce ring endomorphisms on BP*X for any space X)9 which we will denote by Γ{BP), has a submonoid analogous to the monoid of multiplicati...

Figure 2. (A) bp-s-PFG experiments for both components of the emulsion. Note that the signal decay is isotropic for both. (B) Angular bpd-PFG experiments with tm=0 ms, reveals the presence of μA for both compartments. (C) Angular bp-d-PFG experiments with long tm= reveals that toluene is diffusing within spheres, and the presence of csA for water, demonstrating that the water molecules are trap...

IMPORTANCE Low levels of vitamin D are associated with elevated blood pressure (BP) and future cardiovascular events. Whether vitamin D supplementation reduces BP and which patient characteristics predict a response remain unclear. OBJECTIVE To systematically review whether supplementation with vitamin D or its analogues reduce BP. DATA SOURCES We searched MEDLINE, CINAHL, EMBASE, Cochrane ...

BACKGROUND Angiotensin converting enzyme (ACE) is a possible candidate gene that may influence both body fatness and blood pressure. Although several genetic studies have been conducted in adults, relatively few studies have examined the contribution of potential candidate genes, and specifically ACE I/D, on adiposity and BP phenotypes in childhood. Such studies may prove insightful for the dev...