BACKGROUND Despite widespread immunization programs, a clear increase in pertussis incidence is apparent in many developed countries during the last decades. Consequently, additional immunization strategies are considered to reduce the burden of disease. The aim of this study is to design an individual-based stochastic dynamic framework to model pertussis transmission in the population in order...

UNLABELLED Worldwide, paracetamol is administered as a remedy for complaints that occur after vaccination. Recently published results indicate that paracetamol inhibits the vaccination response in infants when given prior to vaccination. The goal of this study was to establish whether paracetamol exerts similar effects in young adults. In addition, the effect of timing of paracetamol intake was...

Objectives. To assess the immunogenicity of intradermal (ID) booster doses of Purified Chick Embryo Cell rabies vaccine (PCECV, Rabipur) administered to Thai schoolchildren one, three and five years after a primary ID pre-exposure (PrEP) vaccination series. Methods. In this follow-up study of a randomized, open-label, phase II clinical trial, two simulated post-exposure booster doses of PCECV w...

BACKGROUND Haemophilus influenzae serotype b (Hib) has yet to be eliminated despite the implementation of routine infant immunization programs. There is no consensus regarding the number of primary vaccine doses and an optimal schedule for the booster dose. We sought to evaluate the effect of a booster dose after receiving the primary series on the long-term disease incidence. METHODS A stoch...

Whooping cough remains a problem despite vaccination, and worldwide resurgence of pertussis is evident. Since cellular immunity plays a role in long-term protection against pertussis, we studied pertussis-specific T-cell responses. Around the time of the preschool acellular pertussis (aP) booster dose at 4 years of age, T-cell memory responses were compared in children who were primed during in...

For booster vaccination of previously immunized persons with potential exposure to rabies, the World Health Organization recommends 2 doses of cell-culture vaccine administered intramuscularly or intradermally on days 0 and 3. We believe that four 0.1-mL intradermal booster doses given on a single day could be used at no risk to the recipient. We studied use of a single booster vaccination on d...

BACKGROUND Antibody levels wane rapidly after Meningococcal serogroup C conjugate (MenCC) vaccination in young children, rendering the need for an adolescent booster dose. It is not clear whether circulating memory B cells are associated with persistence of MenC-specific antibody levels. METHODS Measurement of MenC-specific IgG and IgA memory B cells and levels of serum and salivary MenC-spec...

Transplacentally transferred antibodies induced by maternal pertussis vaccination interfere with infant immune responses to primary vaccination. We evaluated whether this interference remains in toddlers after booster In a prior phase IV, observer-blind, placebo-controlled, randomized study (NCT02377349), pregnant women Australia, Canada and Europe received intramuscular tetanus-reduced-antigen...

PURPOSE Active reduced dose tetanus-diphtheria-acellular pertussis (Tdap) vaccination for adolescents and adults is necessary because waning immunity after primary diphtheria-tetanus-pertussis vaccination is related to the recent emergence of pertussis. This study was conducted to compare the immunogenicity and protection efficacy against Bordetella pertussis between a new GCC Tdap vaccine and ...

Citation: van der Lee S, van Rooijen DM, de Zeeuw-Brouwer M-L, Bogaard MJM, van Gageldonk PGM, Marinovic AB, Sanders EAM, Berbers GAM and Buisman AM (2018) Robust Humoral and Cellular Immune Responses to Pertussis in Adults After a First Acellular Booster Vaccination. Front. Immunol. 9:681. doi: 10.3389/fimmu.2018.00681 robust Humoral and Cellular immune responses to Pertussis in adults after a...