Twenty-seven alcoholic patients were studied for folate status. Twenty-two (81%) had neutrophil hypersegmentation and were detected as folate deficient by also having low serum folate, erythrocyte folate, lymphocyte folate and/or an abnormal peripheral blood lymphocyte deoxyuridine suppression test. Seventeen (63%) had an abnormal lymphocyte deoxyuridine suppression test and all 17 were correct...

Bone marrow is a complex organ containing undifferentiated cells from which the various constituents of blood originate. Under the control of hormones, cytokines and growth factors, normal marrow is susceptible to proliferation or suppression secondary to multiple influences, to include infection, medications, radiation, toxins, neoplasms, and nutritional deficiencies, among others. While histo...

background: recently grapefruit juice is known to enhance the bioavailability of several clinically important drugs such as nifedipine, terfenadine, cyclosporine, ethinylestradiole, midazolam, and triazolam. cyclosporine is an immunosuppressive agent that used in transplantation for preventation of chronic rejection. grapefruit increase in cmax and auc of drug mediated by suppression of cyp3a4 ...

background: hematological abnormalities are a common complication of hiv infection and occur in all stages of the infection. these abnormalities increase as the disease advances. we aimed to evaluate the diagnostic utility of bone marrow sampling in hiv-positive patients. methods: 40 hiv-infected individuals were screened for hematological abnormalities. investigations such as iron studies, hem...

PURPOSE Palbociclib (PD-0332991) is the first selective cyclin-dependent kinase (CDK) 4/6 inhibitor approved for metastatic breast cancer. Hematologic effects, especially neutropenia, are dose-limiting adverse events for palbociclib in humans. EXPERIMENTAL DESIGN Reversible hematologic effects and bone marrow hypocellularity have been identified in toxicology studies in rats and dogs after pa...

Granulocyte colony-stimulating factor (G-CSF), the prototypical mobilizing cytokine, induces hematopoietic stem and progenitor cell (HSPC) mobilization from the bone marrow in a cell-nonautonomous fashion. This process is mediated, in part, through suppression of osteoblasts and disruption of CXCR4/CXCL12 signaling. The cellular targets of G-CSF that initiate the mobilization cascade have not b...

----------------------WARNINGS AND PRECAUTIONS ---------------------­ Bone Marrow Suppression: Mea sure blood counts prior to treatment initiation and before every dose of Xofigo. Discontinu e Xofigo if hematologic values do not recover within 6 to 8 weeks after treatment. Monitor patients with compromised bone marrow reserve closely. Discontinue Xofigo in patients who experience life-threateni...

A girl with intractable epilepsy who received high dose valproic acid showed bone marrow suppression, which improved after the end of valproic acid treatment and the administration of supportive treatments. Valproic acid markedly suppressed the in vitro colony growth in this patient. It is believed that high dose valproic acid treatment directly suppressed the growth of haematopoietic progenito...