The genotoxic effect of endosulfan and the modulatory effect of vitamin C in growing albino rats were studied by bone marrow micronucleus assay. Seven days old male Wistar rats were treated with 3, 6, 9, 12mg/kg Endosulfan orally (10 pups/group),for up to 60 days, at intervals of 24h. For 2 more groups (n=10/group), Endosulfan 9mg/kg and 12mg/kg was administered along with vitamin C (20mg/kg). ...

Abstract Maleic acid polymer scale inhibitor is a new domestic seawater desalination inhibitor. This study tested the acute oral toxicity, sub-chronic toxicity and genotoxicity of this The LD 50 obtained from test was 6810 9260 mg/kg·BW for male female rats, as well 1/5, 1/10 1/20 were dose test. It showed weight rats with high significantly lower than control group during exposure period ( p &...

Background: Although numerous natural or synthetic drugs have been tested for their radioprotective capacity, yet no suitable drug has been introduced for routine clinical use. In this study the radioprotective effect of "a new herbal immunomodulator" commercially known as IMOD, specifically made to decrease the side effects of HIV virus, was investigated on mouse bone marrow cells. M...

Introduction: Hematopoiesis is an on going process mammalian marrow system. A few cells from the nucleated cells of bone marrow are hematopoietic cells which include primary stem cells, precursor cells and progenitor cells. Primary stem cells and progenitor cells are able to produce colonies in culture medium (CFU-C) and irradiated mouse spleen (CFU-S). A hematopoietic cell is alive and act...

Beryllium metal has physical properties that make its use essential for very specific applications, such as medical diagnostics, nuclear/fusion reactors and aerospace applications. Because of the widespread human exposure to beryllium metals and the discrepancy of the genotoxic results in the reported literature, detail assessments of the genetic damage of beryllium are warranted. Mice exposed ...

Mycotoxins are natural food and feed contaminants produced by several molds. The primary mode of exposure in humans animals is through mixtures. Aflatoxin B1 (AFB1) sterigmatocystin (STER) structurally related mycotoxins that share the same biosynthetic route. Few vivo genotoxicity assays have been performed with STER. In present study, Wistar rats were dosed orally STER (20 mg/kg b.w.), AFB1 (...

With respect to radiation damage to humans, it is important to seek possible radioprotectants to modify the normal response of biological systems to radiation-induced toxicity or lethality. For this reasons, the search for less-toxic radiation radioprotectants has spurred interest in the development of different compounds. The radioprotective effects of citrus extract were investigated by using...

With respect to radiation damage to humans, it is important to seek possible radioprotectants to modify the normal response of biological systems to radiation-induced toxicity or lethality. For this reasons, the search for less-toxic radiation radioprotectants has spurred interest in the development of different compounds. The radioprotective effects of citrus extract were investigated by using...

The potential genotoxicity of the rodent liver carcinogen p-dimethylaminoazobenzene (DAB) was evaluated in compliance with the guidelines for genotoxicity studies of drugs (Notification No. 1604, Nov. 1, 1999, Ministry of Health and Welfare, Japan) and the OECD guidelines for testing chemicals. DAB was clearly positive in both the bacterial reverse mutation test (Ames test) and in vitro chromos...