AIMS The main purpose of this paper is to describe the relationship between serum concentrations of glibenclamide and its main metabolites and the effects on blood glucose levels, the clinically most relevant parameter to assess in diabetes. METHODS Serum concentrations and blood glucose lowering effects (expressed as percent blood glucose reduction vs placebo) of glibenclamide (Gb) and its a...

Metabolomics is a powerful technology with broad applications in life science that, like other -omics approaches, requires high-quality samples to achieve reliable results and ensure reproducibility. Therefore, along with quality assurance, methods to assess sample quality regarding pre-analytical confounders are urgently needed. In this study, we analyzed the response of the human serum metabo...

Makouei sheep is one of the famous breeds in Iran which is reared in Azerbaijan province for their meat, milk and wool. Fifty clinically healthy Makouei ewes were selected to study the variations in energy-related blood metabolites during peri-partum period. Blood was collected from Jugular vein from each sheep on day 7 before the expected lambing time, day of parturition and also day 7 postpar...

Conventionally, the assessment of adrenal responses to stress relies on blood sample collection. However, blood collection from animals is impossible without restraint or immobilisation that influences results. This study was undertaken to validate recently established enzyme immunoassays that measure faecal glucocorticoid metabolites in elephants, and to perform a preliminary investigation int...

this experiment was conducted to evaluate the effects of different levels of nettle (urtica dioica) a medicinal plant in starter and grower feeds on performance, carcass traits, blood biochemical and immunity parameters of broilers. a completely randomized design was used with 324 broilers (ross-308) divided in nine treatments and three replicates (with 12 birds in each replicate) 1 to 42 days....

The influence of dietary oxidized oil was studied on laying hen performance, egg quality and blood metabolites.  Experiment was conducted on 160 laying hens (Hy-Line W-36, 54-61 wk of age) in a completely randomized design with five treatments and four replicated cages containing eight birds per cage. Dietary treatments replaced fresh soybean oil in the control diet (3% fresh soybean oil, 15.25...

introduction: cigarette smoking affects nitric oxide production. the aim of this study was to determine associations between tobacco smoke and serum nitric oxide metabolites (nox) concentration. methods: serum nox concentration was measured by the griess method in 230 nonsmokers, 238 active, 196 passive and 29 waterpipe smokers. subjects were selected from participants of tehran lipid and gluco...

this study was conducted to evaluate the effects of different dietary levels of full fat safflower seed (0, 5, 10, 15 and 20% of diet) on performance, carcass characteristics and selected blood metabolites of broiler chickens from arbor acres plus strain. the experiment was designed with 350 commercial one-day-old male broiler chickens using completely randomized design with 5 dietary treatment...