This report is the first of a series on a method for treatment of hypertension by oral hexamethonium chloride and hydrazinophthalazine. When strictly followed blood pressure was maintained at reasonable or normal levels in 80 per cent of 258 cases of severe hypertension. The malignant stage, when present, was reversed. Renal insufficiency and severe cerebral atherosclerosis limit the effectiven...

Hexamethonium by subcutaneous injection in doses of 10 to 75 mg. of the ion every 8 or 12 hours produced significant reductions of arterial pressure and symptomatic improvement in a high percentage of patients with benign or malignant hypertension. Methods for preventing tolerance and undesirable side effects are presented, and the advantages as well as the limitations of hexamethonium therapy ...

This report is the first of a series on a method for treatment of hypertension by oral hexamethonium chloride and hydrazinophthalazine. When strictly followed blood pressure was maintained at reasonable or normal levels in 80 per cent of 258 cases of severe hypertension. The malignant stage, when present, was reversed. Renal insufficiency and severe cerebral atherosclerosis limit the effectiven...

The response of atrial pressure, venous pressure, pulse and respiratory rates to intravenous hexamethonium in 38 selected patients was studied. The drug seemed more effective where vascular tone was greater. Increased venous tone was indicated in congestive heart failure. The possible useful role of intravenous hexamethonium as an adjunct in the treatment of congestive heart failure was conclud...

objective : this study aims to describe the blood pressure profile of newborns of preeclampsia mothers in vali-e-asr hospital during 2003-2004. materials and methods : in this cross-sectional descriptive analytical study 200 mothers and their newborns were studied. blood pressure of all newborns was checked by oscillometric method on the first day after birth and recorded in a questionnaire alo...

Newborn male rats from the New Zealand colony with genetic hypertension (hypertensive rats) and from a normotensive colony (controls) were immunosympathectomized by injections of antiserum to nerve growth factor. Blood pressure of immunosympathectomized hypertensive rats aged 63 days (128±2 mm Hg) was significantly less (P<.001) than that of untreated hypertensive rats (176 ± 3 mm Hg) of the sa...

It has been known for many years that in certain cases of mitral stenosis the pulmonary arterial pressure may be disproportionately high. More recently it has been shown that this pressure, which is due to an increase in the pulmonary vascular resistance, may rise still further on effort (Bayliss et al., 1950; Eliasch et al., 1952). There is considerable debate as to the mechanism and significa...

IN A PREVIOUS study it was demonstrated that hexamethonium, although a potent anticholihergic compound capable of lowering blood pressure for short periods, is not satisfactory as a single drug for the longterm treatment of severe hypertension.' While this study w-as in progress, preliminary clinical iinvestigationi of hydralazine (Apresoline) demonstrated this compound to be partially effectiv...

Sir Horace Smirk deserves much of the credit for establishing the benefits of reducing blood pressure. He was one of the main early proponents of the idea that it was the raised intra-arterial pressure itself that caused many of the cardiac and vascular complications of hypertension. His training in both pharmacology and internal medicine enabled him to devise practical methods for successful t...

Sympathetic activity is enhanced in heart failure and hypertensive rats. The aims of the current study were: i) To investigate the association between renal sympathetic nerve activity (RSNA) and mean arterial pressure (MAP) in response to intravenous injection of the ganglionic blocker hexamethonium; and ii) to determine whether normal Wistar rats and spontaneously hypertensive rats (SHRs) diff...