Platelet aggregation inhibitory effect and anticoagulant properties of fractions separated from the venoms of Cerastes persicus fieldi and Echis carinatus were investigated. The partial fractionation was performed on a Sephadex G-100 column. Two fractions separated from Cerastes persicus fieldi showed anti platelet aggregation activity on ADP (200 µM)-induced platelet aggregation (ca 80% inhibi...

although some venoms and their isolated compounds have been shown to have antibacterial properties, most have not been investigated for such activity. echis carinatus is one of the most venomous snakes in the world and has an effective haematotoxic venom that destroys endothelial cells and causes haemorrhagia. in this study, the antibacterial activity of iranian snake echis carinatus venom agai...

A dysprothrombin designated prothrombin Segovia was isolated from the plasma of an individual with normal prothrombin antigen and prothrombin activity lesser than 25% of the control prothrombin activity. Activation by prothrombinase complex showed a lower amidolytic than clotting activity, which suggests a lesser generation of active intermediates than normal prothrombin. When prothrombin Segov...

The venoms from central Asian snakes (Echis carinatus, Echis multisquamatus, Vipera ursini, Vipera lebetina, Agkistrodon halys halys and Naja naja oxiana) contain several enzymes with amidolytic- and procoagulant activity. We have characterized the activities and the mol. wts of the venom enzymes that are able to convert a number of commercially available chromogenic substrates for activated co...

objective(s): snake venoms contain complex mixture of proteins with biological activities. some of these proteins affect blood coagulation and platelet function in different ways. snake venom toxin may serve as a starting material for drug design to combat several pathophysiological problems such as cardiovascular disorders. in the present study, purification of anticoagulation factor from veno...

livid and watery serum oozes out of the puncture. Headache and in some delirium supervenes and increases. Sense of sinking is very urgent in some. The characteristic sign of capillary bleeding now begins inasmuch as all the mucus surfaces bleed. Heart presents to be weak and with distinct systolic murmur, sharp and shrill in tone, breathing now becomes hurried, patient exhausted. Tetanic spasm ...

Sir,?I liave lately received from Mr. Baini Parshad, B.Sc., Zoological Laboratory, Lahore, a snake for identification, with the report that a native had succumbed to the effects of its bite. The specimen proved to be an Echis carinata, one foot two inches in length. A native about 38 years of age was bitten on the 18th June in the jungle, just above the ankleA companion captured and killed the ...