Morphological and radiological methods were used to study regeneration of the damaged bone of rat mandibles after application of platelet-enriched fibrin clot. A bone hole was artificially created, and in the natural course of regeneration, the hole was immediately filled with blood and there a blood clot formed. After one week of healing, separate islands of young bone tissue appeared. After t...

Abstract Background Colloid fluids supplemented with adequate combinations of coagulation factor concentrates the capability to restore could be a desirable future treatment component in massive transfusion. Methods Starting from and blood cell-free albumin solution we added Prothrombin Complex Concentrate, Fibrinogen Concentrate Factor XIII different concentrations analyze their properties thr...

Fibrinolysis is a cascade of proteolytic reactions occurring in blood and soft tissues, which functions to disintegrate fibrin clots when they are no more needed. In order to elucidate its regulation in space and time, fibrinolysis was investigated using an in vitro reaction-diffusion experimental model of blood clot formation and dissolution. Clotting was activated by a surface with immobilize...

BACKGROUND AND PURPOSE The purpose of this study was to develop a novel MRI method for imaging clot lysis in a rat embolic stroke model and to compare tissue plasminogen activator (tPA)-based clot lysis with and without recombinant Annexin-2 (rA2). METHODS In experiment 1 we used in vitro optimization of clot visualization using multiple MRI contrast agents in concentrations ranging from 5 to...

the patient was a 67-year-old female who presented with severe rectal bleeding since three days prior to hospital admission. she complained of mild abdominal pain. rectal examination revealed the presence of fresh blood and a clot. she had a normal upper endoscopy. a colonoscopy showed a large clot with bloody secretions up to the cecum, with no obvious origin. because of the severity of bleedi...

INTRODUCTION Although fibrinolytic treatment has been used for decades, the interactions between the biochemical mechanisms and the mechanical forces of the streaming blood remain incompletely understood. Analysis of the blood clot surface in vitro was employed to study the concomitant effect of blood plasma flow and recombinant tissue plasminogen activator (rt-PA) on the degradation of retract...

BACKGROUND Dabigatran reduces stroke in atrial fibrillation. Pulmonary veins (PVs) and left atrium (LA) play a critical role in the pathophysiology of atrial fibrillation. We investigated the effects of thrombin, blood clot solution, and dabigatran on PVs and LA. METHODS AND RESULTS Conventional microelectrodes were used to record the action potentials in isolated PV and LA preparations befor...

W hen a blood clot forms in the deep veins of the body, it is called deep vein thrombosis (DVT). DVT occurs most commonly in the leg; however, it can occur anywhere in the body, such as the veins in the arm, abdomen, pelvis, and around the brain. A complication of DVT in legs and arms is pulmonary embolism (PE). A PE occurs when a blood clot breaks off from a DVT and travels through the blood s...

BACKGROUND Drug-eluting stents deliver potent compounds directly to arterial segments but can become clot laden when deployed. The question arises as to whether thrombi affect drug elution and arterial uptake. METHODS AND RESULTS Paclitaxel transport and retention were assessed in clots of different blood components. Diffusivity, affected by clot organization, is fastest in fibrin (approximat...