Colorectal cancer remains one of the major cancer- related deaths despite progress in the treatment during past decades. Detection of disease at earlier stages reduces its mortality. The aim of current study was to investigate expression of Cytokeratin 19 (CK19), Cytokeratin 20 (CK20) and Guanylyl Cyclase C (GCC) mRNA in peripheral blood of non- metastatic colorectal cancer patients which may r...

background: transcriptional silencing of tumor suppressor genes and tumor related genes like gstp1 by methylation of promotor region cpg island is believed to be an important mechanism in tumorigenesis. the gstp1 gene encodes the enzyme glutathione s-transferase pi which defends the cells against oxidative damage and electrophilic carcinogens. methods: to gain insight into the role of epigeneti...

background: regulatory t cells (tregs) and myeloid-derived suppressor cells (mdscs) are two main regulatory cells modulating the immune responses in inflammation and cancer. objective: to investigate and compare tregs and mdscs in peptic ulcer and gastric cancer. methods: patients with dyspepsia were selected and divided into three groups of non-ulcer dyspepsia (nud, n=22), peptic ulcer disease...

Background: Chromosomal alterations play an important role in carcinogenesis. Enhanced chromosomal radiosensitivity is shown for many cancer predisposition conditions including breast cancer. In this study chromosomal radiosensitivity and the frequency of background sister chromnatid exchanges (SCE) in lymphocytes of normal individuals and breast cancer patients was compared. Materials...

background: blood stream infection is one of the main causes of morbidity and mortality in patients with cancer. the purpose of this study was to evaluate the prevalence of aerobic and anaerobic-bacteremia in hospital inpatients with cancer and to determine the antibiotic resistance profile in isolated organisms in kerman, southeast iran.   methods: total of 240 blood cultures from 136 patients...

background : cytokines produced by different subsets of t cells are the key mediators to adjust the quality of immune responses. despite evidence of induction of an immune reaction against tumors such as breast cancer, not all responses are protective. in this study we attempt to evaluate the expression profile of several cytokines from the t helper 1 and 2 subsets in blood cells from patients ...

leukemia is a blood disease which is caused by the inhibition of differentiation and an increased proliferation rate. nature has been known as a rich source of medically useful substances. high diversity of bioactive molecules extracted from marine invertebrates, makes them ideal candidates for cancer researches. the study has been done to investigate cytotoxic effects of dichloromethane brittl...