Blastic phase (BP), the terminal phase of chronic myeloid leukemia (CML), can occur in any of the hematopoietic lineages. Extramedullary blastic crisis (EBC) is a rare form of blastic crisis, which has an extremely poor prognosis. As the tyrosine kinase inhibitor (TKI), Dasatinib is a more effective treatment drug than Imatinib and Nilotinib for this type of CML, because it has greater potency ...

Serum total lactic dehydrogenase (LDH) levels were examined in 42 patients with acute leukemia, 9 patients with chronic myeloid leukemia, 6 of them in blastic crisis, and 53 patients with lymphoma and other lymphoproliferative disorders. The mean range of serum LDH leveles in Hodgkin's and non-Hodgkin's lymphoma was 402 +/- 210 IU/liter and 313 +/- 113 IU/liter, while that of patients with nonm...

Clinical and pathological studies of cutaneous T-cell lymphomas (CTCL) reveal variations in tumor cell morphology and surface membrane phenotype that are of diagnostic and prog nostic importance. Our study investigates blastic transformation and surface antigen change on CTCL cells in vitro under the influence of tumor-promoting phorbol ester (TPA) and phytohemagglutinin. Both agents transforme...

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare acute leukemia subtype characterized by clonal expansion of dendritic-lineage cells.1 These cells are identified immunophenotypically by weak CD45 expression and coexpression of the CD4 and CD56 antigens in the absence of other lineage-specific markers.2,3 Previously known as blastic natural killer (NK)-cell lymphoma or CD4+/CD56+ h...

Plasmacytoid dendritic cells (PDC) constitute a small subset of normal bone marrow (BM) but have also been shown to be present, sometimes in large numbers, several hematological malignancies such as acute myeloid leukemia with RUNX1 mutation, chronic myelomonocytic or, obviously, blastic plasmacytoid cell neoplasms. These reported display somewhat variable immunophenotypic features different co...

NK/T-cell lymphoma (NKTCL) is characterized by the expression of the NK-cell antigen CD56. Non-nasal NK/T-cell lymphomas are subdivided into primary cutaneous and 4 subtypes of secondary cutaneous lymphomas; nasal type, aggressive, blastic (blastoid), and other specific NK-like cell lymphoma. Aggressive NK/T-cell lymphoma/leukemia is a rare leukemic variant of nasal type NKTCL. We herein report...

Blastic plasmacytoid dendritic cell neoplasm is a rare, aggressive tumor characterized by skin and/or marrow infiltration by CD4(+) CD56(+) cells. Historically, the tumor was variably thought to arise from either monocytes, T cells or NK cells giving rise to terms such as CD4(+)/CD56(+) acute monoblastic leukemia, primary cutaneous CD4(+)/CD56(+) hematodermic tumor and blastic NK-cell lymphoma....

Cell cycle characteristics, phagocytosis and maturation of immature white blood cells from seven patients with Ph’-positive chronic myelocytic leukemia were studied in vitro. In five patients whose cells contained only one Ph’ chromosome there were two in early stable phase, one in transitional phase, and two in blastic crisis. The other two patients had cell lines with more than one Ph1 chromo...