The search for new immunopharmacological chemical agents to treat various diseases caused by bacteria, fungi, and protozoa, such as leishmaniasis, for example, has led to the exploration of potential products from plant species and their main active ingredients. Antimonial drugs are the current treatment for leishmaniasis. These drugs cause major side effects and frequent discontinuation of tre...

The importance of chamomile (Chamomilla recutita) inflorescence is widely known in classical and folk medicine, with the largest group its effective constituents forming essential oil (chamazulene, a-bisabolol, α-farnesene, trans-β-farnesene, spathulenol, cis/trans-en-in-dicycloethers). Among cultivated species, Hungarian BK-2 contains more chamazulene than German Degumil type, which mainly for...

The essential oils of leaves and twigs from the Euphorbiaceous Croton draconoides, C. urucurana and Julocroton triqueter were obtained and analyzed by GC and GC-MS. In total, 101 volatile constituents were identified, comprising an average of 90% of the oil, mostly made up of mono- and sesquiterpenes. The monoterpene hydrocarbons varied from 1.2 to 40.2%, the sesquiterpene hydrocarbons from 34....

Objetivo: Avaliar a possível atividade ansiolítica de compostos presentes no extrato padronizado camomila por meio da interação com o receptor GABAa, como também analisar parâmetros farmacocinéticos das moléculas escolhidas ferramentas computacionais. Método: Simulação proteína-ligante apigenina, alfa-bisabolol e camazuleno, docagem molecular comparadas diazepam. Por fim, os dos três foram calc...

Plant habit and production of secondary metabolites in chamomile plants depend on endogenous and exogenous factors that can be divided into two groups (FRANZ 1982): a) morpho-ontogenetic variability, b) genetic variability or genetic determinateness. The activity of these factors is reflected in biomass production, flower drug production, content and composition of essential oil and some other ...

The chemical composition and antimicrobial activity of essential oils obtained from three Brazilian plant species-leaves and branches of Eremanthus erythropappus (Asteraceae), leaves of Plectranthus barbatus, and leaves of P. amboinicus (Lamiaceae)-were determined. Analysis by GC/MS and determination of Kovats indexes both indicated δ-elemene (leaves-42.61% and branches-23.41%) as well as (-)-α...

The aerial parts of Carthamus lanatus (Asteraceae) afforded four new oxygenated bisabolane fucosides, 10-hydroperoxy-bisabola-2,11-diene 7-O-beta-D-fucopyranoside, 11-hydro-peroxy-bisabola-2,9-diene 7-O-beta-D-fucopyranoside, 10-hydroxy-bisabola-2,11-diene 7-O-beta-D-fucopyranoside and 11-hydroxy-bisabola-2,9-diene 7-O-beta-D-fucopyranoside together with the known compounds a-bisabolol beta-D-f...

The sesquiterpenoids nerolidol, farnesol, bisabolol, and apritone were investigated for their abilities to enhance bacterial permeability and susceptibility to exogenous antimicrobial compounds. Initially, it was observed by flow cytometry that these sesquiterpenoids promoted the intracellular accumulation of the membrane-impermeant nucleic acid stain ethidium bromide by live cells of Lactobaci...