نتایج جستجو برای: bis hydantoin
تعداد نتایج: 48507 فیلتر نتایج به سال:
Aims: A microorganism with the ability to release methionine from D,L-(2-methylthioethyl) hydantoin (strain 245) was isolated from soil. The aim of this study was the identification of the strain and the adjustment of the conditions of growth and of the enzymatic reaction, in order to achieve high specific activities of bioconversion of the hydantoin. Methods and Results: Strain 245 was identif...
Four new platinum(II) complexes of 3-aminocyclopentanespiro-5-hydantoin (acpsh) and 3-aminocycloheptanespiro-5-hydantoin (achpsh) were synthesized and characterized by elemental analysis, IR and 1NMR spectra. The spectral analyses indicated a cis-square planar structure of the complexes with ligands coordinated via the NH2 group. The complexes were evaluated for in vitro cytotoxicity in murine ...
The mode of action of the antiviral drug 5-(3,4-dichlorophenyl) methylhydantoin (hydantoin) was studied in a cell-free system allowing de novo synthesis of poliovirus. This cell-free system, which is programmed with viral RNA, is suitable for the study of the late stages of poliovirus replication and, thus, for a study of antiviral compounds acting on these late stages. It was shown that, apart...
p300 and its paralog CBP can acetylate histones and other proteins and have been implicated in a number of diseases characterized by aberrant gene activation, such as cancer. A novel, highly selective, orally bioavailable histone acetyltransferase (HAT) domain inhibitor has been identified through virtual ligand screening and subsequent optimization of a unique hydantoin screening hit. Conforma...
The 41 novel acylthiourea derivatives with hydantoin were synthesized in moderate to excellent yields by using 5-(4-aminophenyl)- and 5-(4-aminobenzyl)-hydantoin or 5-(4-aminobenzyl)-thiohydantoin as raw materials and characterized by IR, 1H NMR spectra and elementary analysis. The preliminary bioassay showed that these compounds exhibit certain selectively herbicidal activities with the 91%, 9...
The title compound, 3-amino-5-methyl-5-(4-pyrid-yl)imid-azol-idine-2,4-dione, C(9)H(10)N(4)O(2), was obtained by reaction of 5-methyl-5-(4-pyrid-yl)hydantoin with hydrazine. It crystallizes as a racemate in the tetra-gonal space group I4(1)/a with one mol-ecule in the asymmetric unit. The dihedral angle between the pyridine ring and the five-membered hydantoin ring is 47.99 (3)° In the crystal ...
In the asymmetric unit of the title organic-inorganic hybrid material, 2{H(3)[PW(12)O(40)]}·4C(3)H(4)N(2)O(2)·C(7)H(8)N(4)O(4)·21.5H(2)O, there are four crystallographically independent hydantoin mol-ecules, one dimerized hydantoin mol-ecule, viz. 1,1'-methyl-enebis(imidazolidine-2,4-dione, two independent H(3)PW(12)O(40) mol-ecules and 21.5 solvent water mol-ecules. Nine of the solvent water m...
a mild and efficient one-pot three-component and environmentally benign approach for the synthesis of a wide range of hydantoin annulated derivatives has been described. a multi-component reaction between a carbonyl compounds (ketone or aldehyde), potassium cyanide and ammonium carbonate (as cyanating agent and amine source, respectively leads to the formation of hydantoins. the proposed optimi...
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