This paper presents a new fault detection system in hypnotic sensors used for general anesthesia during surgery. Drug infusion during surgery is based on information received from patient monitoring devices; accordingly, faults in sensor devices can put patient safety at risk. Our research offers a solution to cope with these undesirable scenarios. We focus on the anesthesia process using intra...

THE bispectral index (BIS, Aspect Medical Systems Inc., Newton, MA) is a processed electroencephalographic variable which correlates with depth of hypnosis in adult patients during general anesthesia. It has also been used clinically to guide anesthetic drug administration, and to quantify the pharmacodynamic action of anesthetic drugs in the laboratory setting. BIS has previously been shown to...

OBJECTIVES To examine the rate of osteoporosis (OP) undertreatment and the association between gastrointestinal (GI) events and OP treatment initiation among elderly osteoporotic women with Medicare Part D drug coverage. METHODS This retrospective cohort study utilized a 20% random sample of Medicare beneficiaries. Included were women ≥66 years old with Medicare Part D drug coverage, newly di...

A series of bis(urea) compounds with complementary functional groups similar to the pharmaceutical drug metronidazole and a structural isomer isometronidazole have been synthesized. The gelation properties these were studied in various solvent/solvent mixtures. mechanical strength isomeric gelators was compared using rheology, morphologies xerogels analyzed by scanning electron microscopy. Thes...

Editor—I continue to be confounded by the use of target-controlled propofol infusion (TCI) dosing paradigm as an accepted basis for presenting the scientific study in anaesthesia journals without specific documentation of instantaneous and total dose infusion rates, in conjunction with body weight and duration of infusion at the study point. Although TCI may be utilitarian in the clinical admin...

The effects of 1,3-bis(2-chloroethyl)-1-nitrosourea on the rejoining of X-ray-induced DNA strand breaks were examined in normal human fibroblasts (WI-38) and a simian virus 40-transformed derivative (VA-13) with the use of alkaline sucrose sedimentation. 1,3-Bis(2-chloroethyl)-1-nitrosourea was capable of partially inhibiting repair of X-ray-produced DNA strand breaks in both cell types when th...

results seventy-five patients completed the study. compared to saline, patients who received 1 and 5 mg/kg of aminophylline demonstrated decreased extubation times (mean ± sd) (12.26 ± 7.33 vs. 11.15 ± 8.62 and 10.4 ± 4.78 min, respectively, p = 0.001) with higher bis values (p = 0.001). however, the recovery and discharge times from the pacu were no different between the aminophylline and sali...

THE Bispectral Index (BIS) monitor (BIS® monitor; Aspect Medical System, Inc., Newton, MA) integrates electroencephalographic data via a proprietary algorithm based on empirical data into a nominal 100 to 0 scale, in which 100 represents the awake state and 0 represents the isoelectric electroencephalogram. The BIS® monitor is highly capable of correctly predicting both the loss and recovery of...

The Ugi reaction is found to be a very powerful tool for the synthesis of (pre)tubulysin derivatives, allowing the introduction of various functionalized side chains in only one step. While polar groups such as amides are not well tolerated, unpolar side chains such as allyl or propargyl ether are well accepted. These functionalities also allow subsequent modifications in the side chain, e.g. v...

Several new 2,6-bis(substituted)pyridine ligands and 2,6-bis(substituted)pyridine Ag(I) nitrate complexes were synthesized and characterized spectroscopically. The newly synthesized ligands include pyridine-2,6-bis(3-oxopropanenitrile) (1), pyridine-2,6-bis(2-cyano-N-phenyl-3-oxopropanethioamide) (2), and pyridine-2,6-bis((E)-2-(2-phenylhydrazono)-3-oxopropanenitrile) (3). The newly synthesized...