BACKGROUND AND PURPOSE It remains undetermined whether the use of coumarin anticoagulants associates with cerebral microbleeds in the general population. We investigated whether (1) coumarin use relates to higher prevalence and incidence of microbleeds, (2) microbleeds are more frequent in people with higher maximum international normalized ratios (INRs), and (3) among coumarin users, variabili...

Coumarin and its derivatives are well known for their anti-inflammatory and anti-oxidative effects. In this study, we synthesized 32 coumarin derivatives from commercially available 6-hydroxycoumarin (6HC) and 7-hydroxycoumarin (7HC) and examined their effects on lipopolysaccharide/interferon γ (LPS/IFNγ)-stimulated nitric oxide (NO) production in murine macrophage RAW264 cells. Among these der...

Interfacial electron injection from a photoexcited surface-immobilized dye to semiconductor substrate is key reaction for dye-sensitized photocatalysts. We previously reported that the molecular orientation of heteroleptic Ir(III) photosensitizer on TiO2 nanoparticle surface was important efficient interfacial injection. In this work, overcome weak light absorption ability and improve photoindu...

A new chalcone of the coumarin, C(21)H(18)O(7), containing an annulated α-pyrone ring, was obtained by condensation of the borate complex of ac-yl(hydr-oxy)coumarin with trimethoxy-benzaldehyde. The structure exhibits intra-molecular hydrogen bonding between the hydroxyl oxygen and the ketonic oxygen in the coumarin group. The bicyclic coumarin fragment and the benzene ring form a dihedral angl...

Nano sulfated titania was tested as solid acid heterogeneous catalyst for the synthesis of 4-(Trifluoromethyl) coumarin and coumarin derivatives under solvent-free condition. Factorial design evidenced a positive effect of reaction temperature, amount of catalyst, and solvents.  This nano-sized sulfated titania has been prepared by a sol-gel hydrothermal process. The prepared sulfated titania s...

BACKGROUND There is controversy as to whether coumarin, an ingredient in cosmetics and fragrances, is a contact allergen involved in fragrance allergy. We recently showed that the purity of coumarin is a critical parameter for its allergenicity because coumarin preparations containing trace amounts of contaminants induced cell proliferation in the local lymph node (LN) assay whereas pure coumar...

In this study, we synthesized a novel multifunctional benzoxazine monomer (Coumarin-COOH BZ), possessing both coumarin and COOH groups, through the reaction of 4-methyl-7-hydroxycoumarin, 4-aminobenzoic acid, and paraformaldehyde in 1,4-dioxane, with the structure confirmed using 1H and 13C nuclear magnetic resonance and Fourier transform infrared (FTIR) spectroscopy. Differential scanning calo...

To reduce the risk of hemorrhage, experts advocate prescribing the anticipated therapeutic dose to patients who are beginning coumarin therapy, but until now there was no accurate way to estimate that dose. Using pharmacogenetics-based coumarin therapy, clinicians can now estimate the therapeutic dose by genotyping their patients for single nucleotide polymorphisms (SNPs) that affect coumarin m...