Landaeta M, et al. BMJ Case Rep 2017. doi:10.1136/bcr-2017-221591 Description A 69-year-old man with invasive pancreatic ductal adenocarcinoma underwent pancreaticoduodenectomy and adjuvant chemotherapy. Three years later, a right upper lobe (RUL) lung mass was noted on surveillance imaging, suspicious for disease recurrence. He was treated for bronchitis and remained asymptomatic 4 months late...

Chemokines are small proteins (7-16kDa) that act at G protein-coupled receptors to regulate a variety of physiological and pathophysiological processes1,2). The human immunodeficiency virus Type 1 (HIV-1) principally uses CCR5 and CXCR4 chemokine receptors as coreceptors with CD4 to gain entry into target cells3,4). Therefore, a molecule that binds to the CCR5 receptor could potentially prevent...

We report the rare case of a 19-year-old immunocompetent male suffering both from fungus balls of the sinuses and from chronic rhinosinusitis with massive polyposis. Endoscopic sinus surgery revealed grayish brown necrotic masses embedded in viscous eosinophilic mucus. Inoculated onto petri dishes, these masses as well as the mucus grew a dark pigmented fungus, which was identified as Bipolaris...

Caspofungin inhibits synthesis of beta-D-1,3 glucan, essential to cell walls in Candida and Aspergillus spp., but activity against less common molds is largely uncharacterized. We demonstrate that caspofungin inhibits beta-D-1,3 glucan synthesis and reduces in vitro growth of clinical isolates from the genera Alternaria, Curvularia, Scedosporium, Acremonium, Bipolaris, and Trichoderma.