• The dynamics of nano-cavities in water can be modelled using a two state model. bioactivity proteins an empty aqueous nano-cavity highly compromised. Protein hydration shell formation depends on the biological character solvent. A model describe protein formation. This work explores singular scenarios emerging from nanoscopic cavities, located solutions, that include biomolecules and, as cons...

Protein stability is measured by denaturation: When solvent conditions are changed (e.g., temperature, denaturant concentration, or pH) the protein population switches between thermodynamic states. The resulting denaturation curves have baselines. If the baselines are steep, nonlinear, or incomplete, it becomes difficult to characterize protein denaturation. Baselines arise because the chromoph...

Mass spectrometry has been regarded as one of the most valuable analytical instruments since any compound has its intrinsic mass value. However, mass spectrometry can only be used to measure the mass-tocharge ratio (m/z) of a charged particle. Therefore, ionization process is usually needed unless the particle to be measured has an intrinsic charge. Nevertheless, the ionization efficiency is us...

In this paper, we present a double gate JL-TFET based biosensor by varying the dielectric constant to detect various biomolecules through label-free detection technique. An investigation regarding properties and behavior device has been investigated with help of Silvaco TCAD. It is observed that Junction less TFET advantageous over JLFET TFETdue absence junctions. The proposed shows reduced sho...

We describe the Biomolecule Stretching Data Base that has been recently set up at http://www.ifpan.edu.pl/BSDB/. It provides information about mechanostability of proteins. Its core is based on simulations of stretching of 17 134 proteins within a structure-based model. The primary information is about the heights of the maximal force peaks, the force-displacement patterns, and the sequencing o...

An adaptive tetrazole-derived host provides insight into tetrazolate-biomolecule interactions, and is the first member of a new family of receptors that function in pure water.