Trace element analysis of biological samples can be useful for diagnostics of diseases caused by accumulation of some elements in the organism. The aim of this work was to evaluate the performance of Laser induced breakdown spectroscopy (LIBS) for the determination of elements present in human tissues. We have investigated samples of human liver and human spleen using pulsed Nd:YAG laser operat...

Multiphoton microscopy is becoming a popular mode of live and fixed cell imaging. This mode of imaging offers several advantages due to the fact that fluorochrome excitation is a nonlinear event resulting in excitation only at the plane of focus. Multiphoton excitation is enhanced by the use of ultrafast lasers emitting in the near IR, offering better depth penetration coupled with efficient ex...

Introduction Commercial production of large-area silicon drift detectors (SDDs) heralds an exciting new time in biological elemental analysis. Improved low-energy performance and higher collection efficiencies mean EDS is no longer limited by low count rates and poor solid angles. High count rates can be achieved on all types of materials, including soft biological tissues, without altering nor...

In biological systems that undergo processes such as differentiation, a clear concept of progression exists. We present a novel computational approach, called Sample Progression Discovery (SPD), to discover patterns of biological progression underlying microarray gene expression data. SPD assumes that individual samples of a microarray dataset are related by an unknown biological process (i.e.,...