Objective(s): The rotavirus nonstructural protein 4 (NSP4) is responsible for the increase in cytoplasmic calcium concentration through a phospholipase C-dependent and phospholipase C-independent pathways in infected cells. It is shown that increasing of intracellular calcium concentration in rotavirus infected cells is associated with the activation of some members of protein kinases family su...

background: replacment of cd133+ cell’s β globin gene by using a gene targeting construct containing the β globin gene and essential elements for homologous recombination. materials and methods: pfbggt was amplified, then digested using the nhei and xhoi restriction enzymes, and finally, a 13.3 kb band (naked dna) was extracted from the agarose gel. biological activity of positive and negative ...

objective(s): the rotavirus nonstructural protein 4 (nsp4) is responsible for the increase in cytoplasmic calcium concentration through a phospholipase c-dependent and phospholipase c-independent pathways in infected cells. it is shown that increasing of intracellular calcium concentration in rotavirus infected cells is associated with the activation of some members of protein kinases family su...

statement of problem: odontogenic keratocysts (okc) make up 10-12% of all developmental cysts with dental origin. okcs are classified into parakeratotic and orthokeratotic types, with completely different clinical features. in order to investigate biological behavior of okcs, an immunohistochemical study was designed, using ki-67 antigen as proliferation marker and p53 protein as tumor suppress...

objective: to assess relative biological effectiveness (rbe) of 131i radiation relative to 60co gamma rays in glioblastoma spheroid cells. materials and methods: in this experimental study, glioblastoma spheroid cells were exposed to 131i radiation and 60co gamma rays. radiation induced dna damage was evaluated by alkaline comet assay. samples of spheroid cells were treated by radiation from 13...

Introduction: The photo-thermal therapy by nanoparticles has been recently known as an efficient strategy for the cancer treatment. Carbon nanotubes (CNTs) have been extensively studied in biomedical application due to the easy uptake and high permeability in the cells, biocompatibility in biological environments and also their unique electrical, thermal properties. They genera...