In semantic typology, it is desirable to have quick and easy access to crosslinguistic elicitations describing stimuli from a semantic domain. We explore the use of crowdsourcing for obtaining such data, and compare it with fieldwork data obtained through in-person elicitations. Despite potential concerns about the quality of crowdsourced data, we find no difference in the amount of between-lan...

MOTIVATION The solvent accessibility of amino acid residues plays an important role in tertiary structure prediction, especially in the absence of significant sequence similarity of a query protein to those with known structures. The prediction of solvent accessibility is less accurate than secondary structure prediction in spite of improvements in recent researches. The k-nearest neighbor meth...

Synonymous codons are widely selected for various biological mechanisms in both prokaryotes and eukaryotes. Recent evidence suggests that microRNA (miRNA) function may affect synonymous codon choices near miRNA target sites. To better understand this, we perform genome-wide analysis on synonymous codon usage around miRNA target sites in four plant genomes. We observed a general trend of increas...

Peroxynitrite (ONOO-) is a potent oxidant implicated in a number of pathophysiological processes. The activity of ONOO- is related to its accessibility to biological targets before its spontaneous decomposition (t1/2 approximately 1 s at pH 7.4, 37 degrees C). Using model phospholipid vesicular systems and manganese porphyrins as reporter molecules, we demonstrated that ONOO- freely crosses pho...

Efficient routes were developed for the diastereoselective synthesis of new O-alkylated and C-branched inositols and their corresponding fluoro analogues. The key steps of the synthesis were the easy accessibility of different types of arms in term of configuration (myo and scyllo), the linking method and length, which could modulate the biological properties. These inositol derivatives, bearin...

background & aim :facilitating people’s access to necessary health services is one of the most important strategies to reach social justice within countries’ health system. therefore in-time access to health cares and ensuring desirable results are essential. this study was conducted to evaluate the perception of martyrs’ parents of accessing the services of health monitoring plan. materials an...

What factors determine a protein's rate of evolution are actively debated. Especially unclear is the relative role of intrinsic factors of present-day proteins versus historical factors such as protein age. Here we study the interplay of structural properties and evolutionary age, as determinants of protein evolutionary rate. We use a large set of one-to-one orthologs between human and mouse pr...

Abstract The recent advancements in single-cell technologies, including chromatin accessibility sequencing (scCAS), have enabled profiling the epigenetic landscapes for thousands of individual cells. However, characteristics scCAS data, high dimensionality, degree sparsity and technical variation, make computational analysis challenging. Reference-guided approaches, which utilize information ex...