mesenchymal stem cells (mscs) have the ability to differentiate into neuronal like cells under appropriate culture condition. in this study, we investigated whether mscs derived from human peripheral blood (pb-mscs) can differentiate into neuronal like cells by synergic effect of the growth factors egf, bfgf and noggin. for this purpose, the expression of five neuronal markers (nestin, β iii tu...

historically, biomarkers have been used in two major ways to maintain and improve better health status: first, for diagnostic purposes, and second, as specific targets to treat various diseases.   a new era in treatment and even cure for the some diseases using reprograming of somatic cells is about to be born. in this approach, scientists are successfully taking human skin cells (previously co...

purpose: to evaluate the properties of cultured limbal stem cells for corneal surface reconstruction. methods: specimens of limbal explants were prepared from the eye bank of i.r. iran. the explants were cultured and expanded on acellular amniotic membrane for 21 days. the cultured cells were evaluated for expression of connexin 43 and keratinine k3 by immunocytochemistry and expression of k12 ...

objective(s): prostate cancer is the world’s leading cause of cancer and the second cause of cancer-related death in men after lung cancer. differentiation of prostate adenocarcinoma from benign prostate lesions and hyperplasia sometimes cannot be done on the basis of morphologic findings. considering the fact that in the prostate adenocarcinoma there is no basal cell layer, basal cell markers ...

ahaptoglobinemia is a common phenomenon in tropical countries,where it is probably due to malaria-induced haemolysis. previous studies have suggested that ahaptoglobinemia is more useful than the other parasite detection indexes to estimate the endemicity of malaria. the present study shows the relationship between malaria and haptoglobin, as a genetic marker in balouch population of sistan & b...

conclusions this study on a limited number of patients treated with adjutant anthracyclins-based regimens, revealed that her2/neu is not a unique strong predictor for outcome, thus according to combination of her2/neu status and other clinical factors, it is necessary to distinguish patients at high risk of recurrence. results her2/neu amplification was identified in 19 (38%) of 50 patients. no...

genetic markers are one of the advances which have occured in the genomics era. among genetic markers, molecular markers mainly because of their abundance, are the most widely used them. development of molecular markers has greatly altered genetics and plant breeding. genetic markers indicate the genetic differences between different organs or species. some studies which were conducted during t...

inter simple sequence repeat (issr) markers were used to assess the genetic diversity among 23 outcross and self pollinated populations of fennel collected from different geographical regions of iran and some european countries. the experiment was carried out to determine the effect of self-pollination on morphological traits and genetic diversity in the next generation. fifteen primers produce...

although some vitamins have been shown to prevent glucocorticoids induced osteoporosis in short time, the magnitude of this effect remains to be clarified. the aim of this study was to evaluate protective effect of vitamin d3 on methylprednisolone acetate (mpa) induced osteoporosis in rats. twenty-four male sprague dawley rats were randomly divided into four groups: group a (n = 6), was a base ...