نتایج جستجو برای: biolayer interferometry

تعداد نتایج: 11333  

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2016
Darryl J Bornhop Michael N Kammer Amanda Kussrow Robert A Flowers Jens Meiler

Interaction/reaction assays have led to significant scientific discoveries in the biochemical, medical, and chemical disciplines. Several fundamental driving forces form the basis of intermolecular and intramolecular interactions in chemical and biochemical systems (London dispersion, hydrogen bonding, hydrophobic, and electrostatic), and in the past three decades the sophistication and power o...

Journal: :Protein Science 2021

Infection with SARS-CoV-2 elicits robust antibody responses in some patients, a majority of the response directed at receptor binding domain (RBD) spike surface glycoprotein. Remarkably, many patient-derived antibodies that potently inhibit viral infection harbor few to no mutations from germline, suggesting naïve libraries are viable means for discovery novel neutralizing antibodies. Here, we ...

2018
Anupama Vasudevan Amy Woerner Falko Schmeisser Swati Verma Ollie Williams Jerry P Weir

BACKGROUND The single radial immunodiffusion (SRID) assay, the accepted method for determining potency of inactivated influenza vaccines, measures an immunogenic form of the influenza hemagglutinin. Nevertheless, alternative methods for measuring vaccine potency have been explored to address some of the weaknesses of the SRID assay, including limited sensitivity and the requirement for large am...

2017
Ilaria Gandolfini Cynthia Harris Michael Abecassis Lisa Anderson Oriol Bestard Giorgia Comai Paolo Cravedi Elena Cremaschi J. Andrew Duty Sander Florman John Friedewald Gaetano La Manna Umberto Maggiore Thomas Moran Giovanni Piotti Carolina Purroy Marta Jarque Vinay Nair Ron Shapiro Jessica Reid-Adam Peter S. Heeger

Introduction Measuring the chemokine CXCL9 in urine by enzyme-linked immunosorbent assay (ELISA) can diagnose acute cellular rejection (ACR) noninvasively after kidney transplantation, but the required 12- to 24-hour turnaround time is not ideal for rapid, clinical decision-making. Methods We developed a biolayer interferometry (BLI)-based assay to rapidly measure urinary CXCL9 in <1 hour. We...

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