In the Bayesian approach to internal dosimetry, uncertainty and variability of biokinetic model parameters need to be taken into account. The discrete empirical Bayes approximation replaces integration over biokinetic model parameters by discrete summation in the evaluation of Bayesian posterior averages using Bayes theorem. The discrete choices of parameters are taken as best-fit point determi...

Model describing the biokinetics of strontium for murine rodent is suggested. The model represents modification of the ICRP model for reference human with reduced number of compartments: Blood, Gastrointestinal tract, Soft tissues, Skeleton, Urinary bladder. To estimate transfer rates of the model the published experimental data on strontium retention in body of laboratory and wild mice were an...

Model-structure identification is important for the optimization and design of biokinetic processes. Standard Monod and Tessier functions are often used by default to describe bacterial growth with respect to a substrate, leading to significant optimization errors in case of inappropriate representation. This paper introduces shape-constrained spline (SCS) functions, which share the qualitative...

Biokinetic parameters help to describe the rate of substrate utilization and biomass production or growth by microbial action, which is important design process performance optimization wastewater treatment. Although studies biokinetic aerobic granular sludge (AGS) systems have been increasing lately, significance for each value in terms maximum specific (μ<sub>max</sub>), concentra...

Stochastic fluctuations (or "noise") in the single-cell populations of molecular species are shaped by the structure and biokinetic rates of the underlying gene circuit. The structure of the noise is summarized by its autocorrelation function. In this article, we introduce the noise regulatory vector as a generalized framework for making inferences concerning the structure and biokinetic rates ...

Biokinetic model is a mathematical model which describes the behavior of the Y in human body during the treatment of neuroendocrine tumours. This paper presents calculation of absorbed doses in human organs in biokinetic model Y for DOTATOC therapy. For this purpose, the human body is represented by five compartments: blood, kidneys, urinary bladder, tumour and liver. The input file was develop...

Policy statements providing health and environmental criteria for blood lead (PbB) often give recommendations on an acceptable distribution of PbB concentrations. Such statements may recommend distributions of PbB concentrations including an upper range (e.g., maximum and/or 90th percentile values) and central tendency (e.g., mean and/or 50th percentile) of the PbB distribution. Two major, and ...

INTRODUCTION ..................................................................................... 357 ANTIOXIDANT ACTIVITY ....................................................................... 358 Free Radicals and Oxygen." Lipid Peroxidation and Antioxidants ...................... 358 BIOKINETICS AND BIOAVAILABILITY ..................................................... 361 New Methodology: ...

A new numerical method for solving the inverse problem of internal dosimetry is described. The new method uses Markov Chain Monte Carlo and the Metropolis algorithm. Multiple intake amounts, biokinetic types, and times of intake are determined from bioassay data by integrating over the Bayesian posterior distribution. The method appears definitive, but its application requires a large amount of...