The objective of our work is to improve the osseointegration of titanium (and its alloys) used in dental and orthopedic applications. To do this, we have been coating these metals with glasses whose compositions are based upon Bioglass®, which is a bioactive glass developed by Hench et al. Bioactive glasses have the property of forming an apatite layer (and therefore can chemically bond to bone...

OssiMend® Bioactive (Collagen Matrix Inc., NJ) is a three-component porous composite bone graft device of 45S5 Bioglass/carbonate apatite/collagen. Our in vitro studies showed that conditioned media the dissolution products OssiMend stimulated primary human osteoblasts to form mineralized bone-like nodules one week, basal culture (no osteogenic supplements). Osteoblast differentiation was follo...

Highly porous 45S5 Bioglass(®)-based scaffolds coated with two polymer layers were fabricated to serve as a multifunctional device with controlled drug release capability for bone regeneration applications. An interior poly(d,l-lactide)/poly(ethylene glycol)-(polypropylene glycol)-poly(ethylene glycol) triblock copolymer (Pluronic P123) coating improved the mechanical stability of Bioglass-base...

The aim of the present study was to prepare and characterize bioglass-natural biopolymer based composite scaffold and evaluate its bone regeneration ability. Bioactive glass nanoparticles (58S) in the size range of 20-30 nm were synthesized using sol-gel method. Porous scaffolds with varying bioglass composition from 10 to 30 wt% in chitosan, gelatin matrix were fabricated using the method of f...

The main goal of this study was to histologically evaluate the healing of surgically created defects on the tibiae of adult rats after implantation of bioactive glass. Twenty adult Wistar rats (body weight of 300g) were divided into two groups: bioglass treated group (n=10) and control group (n=10). Unicortical bone defects with 3-mm diameter were performed in both tibiae of the animals and fil...

STATEMENT OF PROBLEM Bioglasses are a series of biocompatible dental materials, which are considered as light conducting inserts in resin composite restorations. Consequently, their chemical stability is more essential when they are used in conjunction with resin composite. OBJECTIVES The aim of this study was to evaluate and compare the chemical stability of Bioglass with dental porcelain an...

In this study, porous titanium composites containing 5, 10 and 15 wt. % nanobioglass were fabricated by space holder sintering process. The pore morphology and phase constituents of the porous samples were characterized by X-ray diffractometry (XRD) and scanning electron microscopy (SEM). The mechanical properties were determined by compression test. The porosity of the sintered samples show...

objective: a clinical challenge of using zirconia frameworks is to achieve adequate bond with different substrates. this study aimed to evaluate the effect of bioglass and silica coating of zirconia substrates on microshear bond strength of resin cement to tetragonal zirconia. methods: this laboratory experimental study was conducted on zirconia discs. a total of 120 ytzp zirconia (zirkonzahn) ...

The aim of this study was to compare, in different periods of time, the compressive and diametral tensile strength of a traditional high viscous glass ionomer cement: Fuji IX (GC Corporation), with two new Brazilian GIC's: Vitro-Molar (DFL) and Bioglass R (Biodinamica), all indicated for the Atraumatic Restorative Treatment (ART) technique. Fifteen disk specimens (6.0mm diameter x 3.0mm height)...

Bone regeneration is a process of vital importance since fractures of long bones and large joints have a highly deleterious impact on both, individuals and society. Numerous attempts have been undertaken to alleviate this severe medical and social problem by development of novel bioactive materials, among which bioactive glass is the most attractive because of its osteoconductive and osteostimu...