Treating biofilm infections on implanted medical devices is formidable, even with extensive antibiotic therapy. The aim of this study was to investigate whether ultrasound (US)-targeted microbubble (MB) destruction (UTMD) could enhance vancomycin activity against Staphylococcus epidermidis RP62A biofilms. Twelve-hour biofilms were treated with vancomycin combined with UTMD. The vancomycin and M...

The formation of biofilm by pathogenic microorganisms has become a problem in the livestock industry since it is considered potential source infection for farm animals while increasing microbial resistance to physical and chemical agents. Some plant extracts, such as soluble wheat extract, have been shown be effective inhibiting or destroying certain micro-organisms under specific conditions. o...

Pseudomonas fluorescens is one of the first colonizers bacterial biofilm in water systems and a member opportunistic premise plumbing pathogens (OPPPs). The aim this study was to examine effect UV light sodium hypochlorite on formation destruction mature P. ceramic tiles. Planktonic bacteria or were exposed (254 nm) for 5, 20 s. 0.4 mg/L 1 min. Mature also increased concentration 2 0.5, h combi...

The recalcitrance of bacterial biofilms to current antimicrobials has presented a major cause clinical recurrence wound infections. These biofilm-associated infections are often present in polymicrobial nature associated with the presence Pseudomonas aeruginosa and Staphylococcus aureus creating large heterogeneity that shares common resistance making pathogen eradication extremely challenging....

PURPOSE Bacterial biofilms on the surface of prostheses are becoming a rising concern in managing prosthetic joint infections. The inherent resistant features of biofilms render traditional antimicrobial therapy unproductive and revision surgery outcomes uncertain. This situation has prompted the exploration of novel antimicrobial strategies. The synergy of ultrasound microbubbles and vancomyci...

This study aimed to determine the antifungal and antibiofilm activities of Agelas dispar on biofilm-producing Candida species. The methanolic extract A. was obtained fraction Ag2 showed inhibitory activity for all 13 strains tested, in concentrations ranging from 2.5 0.15625 mg/mL. Antifungal fungicidal nature seen between 5.0 0.3125 mg/mL against strains. All were classified as biofilm produce...

Biofilms, sedimented microbial communities embedded in a biopolymer matrix cause vast majority of human bacterial infections and many severe complications such as chronic inflammatory diseases and cancer. Biofilms' resistance to the host immunity and antibiotics makes this kind of infection particularly intractable. Antimicrobial peptides (AMPs) are a ubiquitous facet of innate immunity in anim...

Bacterial vaginosis (BV) is a difficult-to-treat recurrent condition in which health-associated lactobacilli are outnumbered by other anaerobic bacteria, such as Gardnerella vaginalis. Certain genotypes of G. vaginalis can produce sialidase, while others cannot. Sialidase is known to facilitate the destruction of the protective mucus layer on the vaginal epithelium by hydrolysis of sialic acid ...

Biofilm formed by Staphylococcus aureus significantly enhances antibiotic resistance by inhibiting the penetration of antibiotics, resulting in an increasingly serious situation. This study aimed to assess whether baicalein can prevent Staphylococcus aureus biofilm formation and whether it may have synergistic bactericidal effects with antibiotics in vitro. To do this, we used a clinically isol...

Biofilm growth on stone surfaces is a significant contributing factor to stone biodeterioration. Current market based biocides are hazardous to the environment and to public health. We have investigated the photo-dynamic effect of methylene blue (MB) in the presence of hydrogen peroxide (H2O2) on the destruction of the cyanobacterium Synechococcus leopoliensis (S. leopoliensis) under irradiatio...