نتایج جستجو برای: biochemical parameter

تعداد نتایج: 347199  

2013
Stefano Mariani

To cope with nowadays MAS complexity, natureinspired coordination models and languages gained increasing attention: in particular, biochemical coordination models. Being intrinsically stochastic and self-organising, the effectiveness of their outcome likely depends on a correct parameter tuning stage. In this paper, we focus on chemical reactions rates, showing that simply imitating chemistry “...

2008
Martin. Brown Fei. He Choujun. Zhan

Parameter estimation of non-linear differential equations has long been an active and challenge research area. Conventionally methods are computationally intensive and often poorly conditioned. In the context of biochemical pathway modeling, a new method focused on this paper is the so-called “collocation” method, which is a nonparametric data smoothing based approach. The statistical property ...

2011
Aleksandr Andreychenko Linar Mikeev David Spieler Verena Wolf

We propose a numerical technique for parameter inference in Markov models of biological processes. Based on time-series data of a process we estimate the kinetic rate constants by maximizing the likelihood of the data. The computation of the likelihood relies on a dynamic abstraction of the discrete state space of the Markov model which successfully mitigates the problem of state space largenes...

Journal: :Journal of theoretical biology 2005
Wolfram Liebermeister

Metabolic response coefficients describe how variables in metabolic systems, like steady state concentrations, respond to small changes of kinetic parameters. To extend this concept to temporal parameter fluctuations, we define spectral response coefficients that relate Fourier components of concentrations and fluxes to Fourier components of the underlying parameters. It is also straightforward...

Journal: :Molecular bioSystems 2008
Stephen J Wilkinson Neil Benson Douglas B Kell

It is commonly the case in biochemical modelling that we have knowledge of the qualitative 'structure' of a model and some measurements of the time series of the variables of interest (concentrations and fluxes), but little or no knowledge of the model's parameters. This is, then, a system identification problem, that is commonly addressed by running a model with estimated parameters and assess...

2017
Fabian Fröhlich Barbara Kaltenbacher Fabian J. Theis Jan Hasenauer

Mechanistic mathematical modeling of biochemical reaction networks using ordinary differential equation (ODE) models has improved our understanding of small- and medium-scale biological processes. While the same should in principle hold for large- and genome-scale processes, the computational methods for the analysis of ODE models which describe hundreds or thousands of biochemical species and ...

2009
Steffen Waldherr Jan Hasenauer Frank Allgower

Populations of heterogeneous cells play an important role in many biological systems. In this paper we consider systems where each cell can be modelled by an ordinary differential equation. To account for heterogeneity, parameter values are different among individual cells, subject to a distribution function which is part of the model specification. Experimental data for heterogeneous cell popu...

Journal: :Bioinformatics 2004
Shuhei Kimura Takuji Kawasaki Mariko Okada Takashi Naka Fumikazu Konishi Akihiko Konagaya

UNLABELLED OBIYagns (yet another gene network simulator) is a biochemical system simulator that comprises a multiple-user Web-based graphical interface, an ordinary differential equation solver and a parameter estimators distributed over an open bioinformatics grid (OBIGrid). This grid-based biochemical simulation system can achieve high performance and provide a secure simulation environment f...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید