Celiac Disease is a worldwide spread condition affecting 1:100-1:200 individuals. It is a permanent food intolerance to ingested gluten in genetically predisposed subjects. In this review we analyze the biochemical markers of the disease going from laboratory findings to histology passing through genetics. Gluten intolerance is a unique model of autoimmune disease in which we can recognize the ...

Serum amylase remains the most commonly used biochemical marker for the diagnosis of acute pancreatitis, but its sensitivity can be reduced by late presentation, hypertriglyceridaemia, and chronic alcoholism. Urinary trypsinogen-2 is convenient, of comparable diagnostic accuracy, and provides greater (99%) negative predictive value. Early prediction of the severity of acute pancreatitis can be ...

background: th e eff ects of chronic valproic acid administration on bone health have been a matter of concern and controversy.in this study, the bone status following valproate intake was assessed by using several bone-related biochemical markers. materials and methods: in this case-control study, 62 epileptic patients and 40 age- and gender-matched controls were enrolled. the patients had bee...

Neuroprotective therapy is likely to be most effective in preventing or minimizing the effects of cerebral ischaemia when given as early as possible after the insult. Neuropsychological testing is the gold standard for assessing minor cerebral damage, but is carried out several days or weeks after surgery and is too late to be useful for instituting therapy. Current intraoperative cerebral moni...

Scientists are searching for biochemical markers for alcoholism that would allow researchers to distinguish easily and reliably between alcoholics and nonalcoholics or between people at risk for alcoholism and those not at risk. Two proposed markers that have been studied intensively are the activity levels of the enzymes platelet monoamine oxidase (MAO) and platelet adenylyl cyclase (AC). Leve...

Besides biochemical parameters such as increased aspartate aminotransferase (GOT), alanine aminotransferase (GPT) and especially gamma-glutamyltransferase (GGT)-values, high blood-methanol levels indicate chronic abuse of alcoholic beverages. The paper will discuss the reliability of these markers. Several blood samples of male chronic alcoholics admitted alcoholized to a withdrawal clinic were...