Traditional Chinese medicine (TCM) is a complex system, which consists of numerous compounds with related mechanisms to maximize therapeutic efficacy with minimal adverse effects. Some new methods disclosing the contribution of these constituents as well as their relationship in the formula are necessary for elucidating the bio-active constituents and the working mechanisms of TCM. In this stud...

Biologically active heterocyclic compounds comprise of largest & manifold family organic compounds. These include Quinolines, Quinazolines, Aminoquinolines, etc and their derivatives. They exhibit multi-faceted biological properties like analgesic, anti-inflammatory, anticonvulsant, antibacterial, antifungal, antidepressant, anticancer, antitubercular &antihistaminic. are considered to ...

BACKGROUND & OBJECTIVES Phlebotomus argentipes (Diptera: Psychodidae), the established vector for kala-azar is presently being controlled by indoor residual spray of DDT in kala-azar endemic areas in India. Search for non-hazardous and non-toxic biodegradable active molecules from botanicals may provide cost-effective and eco-friendly alternatives to synthetic insecticides. The present study wa...

Identification of active compounds from natural products is a critical and challenging task in drug discovery pipelines. Besides commonly used bio-guided screening approaches, affinity selection strategy coupled with liquid chromatography or mass spectrometry, known as ligand fishing, has been gaining increasing interest from researchers. In this review, we summarized this emerging strategy and...

Pyrazole is associated with wide range of biological properties. These ring systems are incorporated into drugs used for AIDS, cancer, anti-viral treatment etc. Pyrazole derivatives are well established in the literature as important biologically active compounds. They have a long history of application in agrochemicals and pharmaceutical industry as herbicides and active pharmaceuticals. Pyraz...

Many species belonging to the Scrophularia genus have been used since ancient times as folk remedies for many medical conditions such as scrofulas, scabies, tumors, eczema, psoriasis, inflammations. The aim of this study was to characterize the matrix metalloproteinases (MMPs) inhibitor compounds of the Scrophularia striata extract by bio-guide fractionation. The aerial parts of S. striata were...

The enormous promise that the sea holds to provide potential lead pharmaceuticals has attracted great interest from the scientific community in the recent years. In an effort to isolate bio-active ingredients from marine sources, investigation of the Red Sea sponge Pseudoceratna arabica has led to the isolation and structure elucidation of the new brominated metabolite hydroxymoloka’iamine (1) ...

Virus particles are probably the most precisely defined nanometre-sized objects that can be formed by protein self-assembly. Although their natural function is the storage and transport of genetic material, they have more recently been applied as scaffolds for mineralization and as containers for the encapsulation of inorganic compounds. The reproductive power of viruses has been used to develo...