The complexation reactions between diacetyl monooxime (Damo), imidazole (Him), histamine (Hist) and histidine (His) with Co2+, Ni2+ and Cu2+ were studied potentiometrically in aqueous solution at 25 °C and m= 0.5 M KNO3. The overall stability constants log b's of species were obtained by computer refinement of p...

Nickel is one of the essential trace elements found in biological systems. It is mostly found in nickel-based enzymes as an essential cofactor. It forms coordination complexes with amino acids within enzymes. Nickel is also present in nucleic acids, though its function in DNA or RNA is still not clearly understood. In this study, complex formation tendencies of Ni(II) with adenine and certain L...

The formation equilibria for the binary complexes of Effortil with Cu, Co, Ni, and Zn metal ions were investigated using potentiometric technique in aqueous medium (t= 37 Co, I= 0.15 mil. dm NaNO3). The formation of binary complexes was inferred from the pH-metric titration curve. The overall stability constants of the complexes formed were obtained using HYPERQUAD 2008 program using from poten...

In [11], Quillen defines the notion of exact category. Each such category N is an additive category together with a suitable collection of sequences called short exact sequences. Quillen constructs a space by gluing simplices to each other, using the exact sequences of N to determine the simplices and the gluing instructions. Then for each n ∈ N he defines KnN as a homotopy group of the space. ...

The changes that SNAREs undergo during exocytosis were studied in permeabilised chromaffin cells treated with Ca(2+), MgATP or botulinum neurotoxin A. High-resolution 2D SDS-PAGE revealed multiple SDS-resistant SNARE complexes having a wide range of sizes and in which SNAP-25 and syntaxin predominate over synaptobrevin. Their formation increased upon Ca(2+)-stimulated exocytosis; notably, the 2...

A neighborliness property of marginal polytopes of hierarchical models, depending on the cardinality of the smallest non-face of the underlying simplicial complex, is shown. The case of binary variables is studied explicitly, then the general case is reduced to the binary case. A Markov basis for binary hierarchical models whose simplicial complexes is the complement of an interval is given.

The aim of this study is to introduce a new methodology for isolation of ectopic rhythms of ambulatory electrocardiogram (ECG) holter data via appropriate statistical analyses imposing reasonable computational burden. First, the events of the ECG signal are detected and delineated using a robust wavelet-based algorithm. Then, using Binary Neyman-Pearson Radius test, an appropriate classifie...

Research of metal complexes with biologically active ligand is one of high scientific and practical interest. Formation of binary and ternary complexes of metal ions such as Cu(II), Co(II), Pb(II), Zn(II) and Cd(II) with biologically important ligand were investigated. Where nucleic acid Adenine (A) used as primary ligand and amino acid Histidine (B) used as secondary ligand. Potentiometric tec...

Ternary complexes of meloxicam (ME) (a poorly water soluble anti-inflammatory drug) with hydroxypropyl-beta-cyclodextrin (HPbetaCD) and either a hydrophilic polymer, namely, polyvinyl pyrrolidone (PVP) or a basic amino acid such as L-arginine, were prepared by the spray-drying technique. The solubilizing efficiency, physical properties and dissolution behaviour of each ternary system of ME-HPbe...

The aim of this study was to enhance the apparent solubility and dissolution properties of flurbiprofen through inclusion complexation with cyclodextrins. Especially, the efficacy of supercritical fluid technology as a preparative technique for the preparation of flurbiprofen-methyl-β-cyclodextrin inclusion complexes was evaluated. The complexes were prepared by supercritical carbon dioxide pro...