In the past few years, the pro-apoptotic molecule Bim has attracted increasing attention as a plausible target for tumor therapy. A variety of normal and pathological systems regulated by Bim, dependent on cell type, apoptotic stimulation, and chemotherapeutic agents, have been documented. Bim promotes anoikis of many tumor cells, such as lung cancer, breast cancer, osteosarcoma, and melanoma. ...

̶ Implementation of BIM in the construction industry relies on sufficient knowledge and skills about BIM in order to gain momentum and success. Thorough understanding of the possibilities as well as challenges related to the application of BIM constitutes essential drivers for the adoption of BIM among all the industry actors throughout the construction process. Thus, there is a need for supply ...

Construction education needs to embrace the opportunities and overcome the challenges presented by Building Information Modeling (BIM) to remain current and relevant. Although a growing number of university architecture, engineering and construction (AEC) programs have begun to offer courses that include BIM content, few programs have strategies in place to fully integrate BIM across curriculum...

The BH3-only Bim protein is a major determinant for initiating the intrinsic apoptotic pathway under both physiological and pathophysiological conditions. Tight regulation of its expression and activity at the transcriptional, translational and post-translational levels together with the induction of alternatively spliced isoforms with different pro-apoptotic potential, ensure timely activation...

BIM is a modeling technology that allows architects and builders to visually create, analyze, and share building models. BIM is gaining a growing importance which may be reflected in the increasing number of owners who demand BIM use. However, despite the perceived uptick in demand for BIM, an industry wide adoption has not yet been reached. Likewise, the adoption of BIM enhanced business pract...

Human T-cell leukemia virus type 1 (HTLV-1), an etiological agent of adult T-cell leukemia, immortalizes and transforms primary human T cells in vitro in both an interleukin (IL)-2-dependent and IL-2-independent manner. Expression of the HTLV-1 oncoprotein Tax transforms the growth of the mouse T-cell line CTLL-2 from being IL-2-dependent to IL-2-independent. Withdrawal of IL-2 from normal acti...

This paper reviews BIM concepts, with a particular focus on its applicability and uptake within the business processes in the construction industry. An exploratory study is being carried out to examine the current state of BIM practices using the instrument of survey questionnaire and literature review. The partial findings from an on-going survey show that, the inevitable need for organisation...

Bim (Bcl-2-interacting mediator of cell death) is a BH3-only protein (BOP), a pro-apoptotic member of the Bcl-2 protein family. The Bim mRNA undergoes alternate splicing to give rise to the short, long and extra long protein variants (Bim(S), Bim(L) and Bim(EL)). These proteins have distinct potency in promoting death and distinct modes of regulation conferred by their interaction with other pr...

The proapoptotic BH3-only protein Bim is a crucial regulator of neuronal apoptosis. Previous studies have indicated the involvement of the c-Jun, FOXO1/3a, and B/C-Myb transcription factors in the regulation of Bim during neuronal apoptosis. However, the mechanism underlying the transcriptional regulation of Bim in activity deprivation-induced neuronal apoptosis has remained unclear. The presen...

The proapoptotic members of the Bcl-2 family can be subdivided into members that contain several Bcl-2 homology (BH) domains and those that contain only the BH3 domain. Although it is known that BH3-only proteins and the multi-BH domain proteins, Bak and Bax, are essential for programmed cell death, the overlapping role of these two subgroups has not been examined in vivo. To investigate this, ...