background: cholangiocarcinoma is an invasive biliary malignancy with poor prognosis. diagnostic accuracy of conventional methods is low which is mainly due to the specific anatomy of the disease. the aim of this study was to evaluate the diagnostic value of biochemical profile and tumor marker of the bile in patients with malignant cholestasis compared to that of choledocholithiasis. methods: ...

This study aimed at applying both growth and survival approaches to compare three native strains of lactobacilli, belonging to Lactobacillus plantarum, Lactobacillus rhamnosus and Lactobacillus acidophilus species, with two commercial probiotic strains in their tolerance to acid and bile. The association between the data obtained from the methods was studied.  The results of the different metho...

introduction: given the importance of identifying common bile duct diameter in diseases diagnoses and being different in different races, this paper aimed to investigate the relationship between the diameter of the common bile duct and demographic factors and drug addiction in patients who referred to the imaging department of imam reza hospital in birjand during the year 1391-1392. methods: th...

Bile acid profiles in serum, urine, and bile from patients undergoing bile drainage and the changes of serum bile acids after bile drainage were studied. Bile acids were separated into non-glucuronidate-non-sulphate, glucuronidated, and sulphated fractions and were measured by mass fragmentography using conjugates of deuterium labelled bile acids as internal standards. Glucuronidated and sulpha...

this study aimed at applying both growth and survival approaches to compare three native strains of lactobacilli, belonging to lactobacillus plantarum, lactobacillus rhamnosus and lactobacillus acidophilus species, with two commercial probiotic strains in their tolerance to acid and bile. the association between the data obtained from the methods was studied.  the results of the different metho...

introduction the incidence of liver damage due to steroid consumption is increasing due to the omnipresence of the idealized body image and the widespread availability of drugs via the internet. the genetic factors underlying individual susceptibility are not presently known. conclusions this case of pxr haploinsufficiency reveals transcriptional regulatory functions activated in the liver unde...

aretaeus of cappadokia, lived in an era when cancer was already a disease, well known for its deadly outcome. inside his momentous treatise, composed of 8 books, he had outlined various types of cancer. he had understood cancer’s fatality and proposed some curative treatments. our manuscript composes the fragments related to cancer, in an effort to present aretaeus’ views on the matter.  he had...

Poorly water-soluble drugs frequently solubilize into bile colloids and this natural mechanism is key for efficient bioavailability. We tested the impact of pharmaceutical polymers on solubilization interplay using proton nuclear magnetic resonance spectroscopy, dynamic light scattering, by assessing flux across model membranes. Eudragit E, Soluplus, a therapeutically used polymer, Colesevelam,...

Unconjugated bile acids in the bile of healthy and diseased humans were determined qualitatively and quantitatively by means of gas-liquid chromatography and gas-liquid chromatography-mass spectrometry, after their isolation by ion-exchange chromatography. In a healthy person and three patients with cholelithiasis, unconjugated bile acids comprised 0.1-0.4% of total biliary bile acids. The bile...