Evidence for the production in viva from pyridoxine of compounds with increased activity for certain lactic acid bacteria (1) and for the production of similar compounds by amination or oxidation procedures in vitro (2, 3) has been reported. Only a limited number of structures for the compounds resulting from amination or oxidation appeared possible; synthesis (4, 5) of certain of these resulte...

Liver cirrhosis (LC) is frequently accompanied by glucose intolerance. The present study was designed to determine whether glycated hemoglobin A1c (HbA1c) and glycated albumin (GA) were predictive markers of glycemia, as determined by a continuous glucose monitoring system (CGMS), in patients with LC. A total of 30 patients with LC, including 3, 19, 5, 2 and 1 with LC due to hepatitis B virus, ...

The terminology and notation used in this paper have been introduced in the following articles: [1], [2], [3], [4], and [5]. For simplicity, we adopt the following rules: Y is a non empty set, a is an element of BVF(Y ), G is a subset of PARTITIONS(Y ), and A, B, C are partitions of Y . One can prove the following propositions: (1) If G is a coordinate and G = {A, B,C} and A 6= B and B 6= C and...

we have simulated the carrier concentration and temporal response characteristics of a back-gated metal- semiconductor-metal (bg-msm) photodetector in one dimension as a function of optical pulse position on the active region in an equilibrium condition (without bias voltage to the photodetector). we have adopted a nonlinear ambipolar transport model to simulate the behavior of photo-generated ...

PURPOSE To report the results of the first pharmacokinetic study in pediatric patients of O(6)-benzylguanine (O(6)BG), which irreversibly inactivates the DNA repair protein alkylguanine-alkyltransferase, thus enhancing the cytotoxicity of nitrosoureas. EXPERIMENTAL DESIGN As part of a Pediatric Oncology Group Phase I study, 120 mg/m(2) of O(6)BG was administered i.v. over 1 h, before 1,3-bis(...

The striatum and the subthalamic nucleus (STN) constitute the input stage of the basal ganglia (BG) network and together innervate BG downstream structures using GABA and glutamate, respectively. Comparison of the neuronal activity in BG input and downstream structures reveals that subthalamic, not striatal, activity fluctuations correlate with modulations in the increase/decrease discharge bal...

Biodegradable polymer-ceramic composites are attractive systems for bone tissue engineering applications. These composites have the combined advantages of the component phases, as well as the inherent ease in optimization where desired material properties can be tailored in a well-controlled manner. This study focuses on the optimization of a polylactide-co-glycolide (PLAGA) and 45S5 bioactive ...

Resistance to temozolomide (TMZ) based chemotherapy in glioblastoma multiforme (GBM) has been attributed to the upregulation of the DNA repair protein O(6)-methylguanine-DNA methyltransferase (MGMT). Inhibition of MGMT using O(6)-benzylguanine (BG) has shown promise in these patients, but its clinical use is hindered by poor pharmacokinetics that leads to unacceptable toxicity. To improve BG bi...