The role of lime in the formation of reactive oxygen species (ROS), i.e., O2-., H2O2, and OH., from betel-quid components (extracts of areca nut and catechu) was investigated in vitro using a chemiluminescence technique and an assay for oxidative DNA damage involving analysis of 8-hydroxy-2'-deoxyguanosine. Of the various areca-nut extracts, the catechin fraction, at alkaline pH, was shown to b...

BACKGROUND Betel nut (Areca nut) is the fruit of the Areca catechu tree. Approximately 700 million individuals regularly chew betel nut (or betel quid) worldwide and it is a known risk factor for oral cancer and esophageal cancer. We performed a meta-analysis to assess the influence of chewing betel quid on metabolic diseases, cardiovascular disease, and all-cause mortality. METHODOLOGY/PRINC...

Introduction: Oral submucous fibrosis (OSMF) is a potentially malignant disorder with a multifactorial etiology. Recent studies have shown that there are increased levels of fibrinogen degradation products (FDP) in the plasma of OSMF patients suggesting its possible role in etiopathogenesis. Purpose: To assess the FDP levels in the plasma of OSMF patients in betel nut chewers and in healthy par...

BACKGROUND Betel nut and betel quid chewing are from major etiological factor for oral cancer. They also increase the risk of systemic diseases such as asthma, diabetes mellitus, metabolic syndrome, myocardial infarction, hypertension, and other cardiovascular diseases. METHODS Sixty three patients of oral cancer in our institution during Jan. 2007 to May 2011 were included in our study. This...

oral submucous fibrosis is chronic progressive condition of oral cavity. the condition is well recognized for its malignant potential. usually the disease initiates with redness, blistering, and ulceration inside the mouth. it is characterized by progressive fibrosis of submucosal tissue. the pathogenesis of oral submucous fibrosis is not well understood. betelquid chewing is the major etiologi...

ion of a hydrogen atom from poly unsaturated fatty acids (PUFA); the hydroxyl radical is capable of starting this reaction sequence [4, 5]. While Piper species are reported to have wide spectrum of biological activity but its antioxidant potential has not been established so far, making it important and interesting to analyze the antioxidant potential of Piper betle leaf extract in the present ...

Eight manuscripts have specifically examined the effects of areca (betel) nut use in pregnant women, seven of which have documented adverse effects on birth weight, newborn neurological status, gender ratio and pregnancy outcomes such as anaemia and miscarriage following areca nut use during pregnancy. A retrospective cohort analysis of migrant and refugee pregnant women attending antenatal cli...

BACKGROUND Oral cancer is the 2nd most common cause of death due to cancer in the south-western coastal region of Taiwan; the standardized mortality of oral cancer is higher than elsewhere in the world. According to the evidence, alcohol, betel-nut and cigarette (ABC) consumption cause oral, nasopharyngeal and related cancers. This study describes the relationships between ABC consumers and hea...

Since antiquity, Piper betel Linn (betel vine; family Piperaceae) has been an important medicinal agent in the various traditional and folk systems of medicine in Southeast Asia countries. The leaves are the most valued plant part and in the past were routinely used as a chewing agent to prevent halitosis. The leaves are also supposed to harden the gum, conserve the teeth and to prevent indiges...