Background. Production of highly pure enantiomers of vicinal diols is desirable, but difficult to achieve. Enantiomerically pure diols and acyloins are valuable bulk chemicals, promising synthones and potential building blocks for chiral polymers. Enzymatic reduction of ketones is a useful technique for the synthesis of the desired enantiomeric alcohols. Here, we report on the characterization ...

Arylalkynes can be converted into α-diketones with the use of a copper catalyst, and also be transformed into vinyl acetates under metal-free conditions, both in the presence of PhI(OAc)2 as an oxidant at room temperature. A series of substituted α-diketones were prepared in moderate to good yields. A variety of vinyl halides could be regio- and stereo-selectively synthesized under mild conditi...

The kinetic method is used to corroborate the description of ground state ionized alpha-diketones as loosely electron-bonded acylium ion dimers: R(1)-C=O(+)---e(-)---(+)O=C-R(2). The abundance ratio of both the acylium ion fragments R(1)CO(+) and R(2)CO(+) (summed to those of their respective secondary fragments) formed upon low energy (5 eV) collision-induced dissociation of several ionized al...

We have discovered new characteristics of D-erythrulose reductase, namely, that it can catalyze reduction of not only D-erythrulose but also such diketones as diacetyl. These substrates have a common structure with two neighboring carbonyls possibly in s-cis plane structure, showing that the enzyme may rigorously distinguish between substrates and other compounds. D-Erythrulose reductase was pr...

BACKGROUND Ferrocene-containing β-diketones and cisplatin, [(NH(3))(2)PtCl(2)], possess strong antineoplastic activity. No information is available regarding the anticancer activity of the corresponding ruthenocene complexes. This study examined the cytotoxicity of stable ruthenocene-containing β-diketones. The results were related to the cytotoxicity of cisplatin and the ease of ruthenium elec...

Four new 1,5-benzothiazepines were synthesized by reaction of o-aminothiophenol with curcumin and curcuminoid β-diketones, in methanol acetic acid. The mechanism involves a Michael addition on the CC double bond affording benzothiazepine two pendant groups, an aryl group adjacent to sulfur atom 1-phenylethanone NH seven membered ring. 1D 2D multinuclear NMR (1H, 13C, 15N, 119F) solution 13C 15N...

An unusual radical fragmentation of an unstrained cyclohexane structure was observed leading to complex 1,2-diketones.