Background: Acinetobacter baumannii is one of the causes of nosocomial infections, especially in the intensive care unit. The emergence of multidrug-resistant strains of A. baumannii has caused many problems. One of the ways to handle the phenomenon of antibiotic resistance is the use of herbal medicines and their derivatives in place of or in combination with antibiotics. The aim of this study...

AMP (Adenozin monofosfat) ile aktifle?tirilen protein kinaz (AMPK), enerji üreten yollar? aktive edip tüketen inaktive ederek homeostaz?n? sa?layan bir düzenleyicidir. AMPK, serin/treonin ailesine aittir ve yap?sal olarak üç alt birimden (?, ? ?) olu?maktad?r. Biri hücresel seviyelerinde art??, di?eri LKB1 (serine–threonine kinase liver B1), CaMKK? (Ca2+/calmodulin-dependent ?), TAK1 veya MLK3 ...

this study investigated the effect of berberine on the hepatic dysfunction and histological damage induced by renal ischaemia/ reperfusion (i/r) at an early stage. there were four groups (n=7). in ber+i/r group, rats received berberine (ber; 15 mg/kg/day) orally for 7 days before induction of ischemia. i/r group received distilled water orally for 7 days. in sham and ber+sham groups in which ar...

materials and methods twelve natural compounds jaceosidin, withaferin a, curcumin, epigallocatechin-3-gallate (egcg), artemisinin, gingerol, ursolic acid, ferulic acid, berberin, silymarin, resveratrol, and indol-3-carbinol were docked against e6 and e7 oncoproteins of high-risk hpv types 16 and 18 using a protein-ligand docking software called autodock4.2. results out of these 12 natural compo...

Many complicated mechanisms are involved in brain ischemia and the role of inflammatory factors in the progression of post-ischemic injury is inevitable. In present study, anti-inflammatory effect of berberine has been investigated in reperfusion injury after acute ischemic stroke. Male Wistar rats weighing 250-270 gr were randomly divided into four cohorts: healthy rats (control, n=20), sham-o...

Objective (s): The anti-fibrotic effect of chronic berberine (BBR) had demonstrated previously in a rat model of bile duct ligation (BDL). The aim of present study was to investigate hepatoprotective effect of BBR nanomicelles on liver cirrhosis induced by BDL in male rats.Materials and methods: After 21 days of drugs’ treatments, the serum and tissue levels of hepatic markers were measured and...