BACKGROUND The biosynthesis pathway of benzoxazole compounds caboxamycin and nataxazole have been recently elucidated. Both compounds share one of their precursors, 3-hydroxyanthranilate (two units in the case of nataxazole). In addition, caboxamycin structure includes a salicylate moiety while 6-methylsalycilate is the third scaffold in nataxazole. Pathways cross-talk has been identified in ca...

We report on the photodynamics of 2-(2'-hydroxyphenyl)benzoxazole (HBO), compared to its amino derivatives, 6-amino-2-(2'-hydroxypheny)benzoxazole (6A-HBO) and 5-amino-2-(2'-hydroxypheny)benzoxazole (5A-HBO) in N,N-dimethylformamide (DMF) solutions. HBO at S0 shows a reversible deprotonation reaction leading to the production of anionic forms. However, for 6A-HBO and 5A-HBO, DMF containing KOH ...

The synthesis of visnaginone-oxime (2 a) and khellinone-oxime (2 b) is reported. Beckmann rearrangement of 2 a and 2b using different cyclising agents was studied. Structure assignement for the produced benzoxazole derivatives and benzisoxazole derivatives was confirmed by chemical and spectral evidences. Utilization of visnaginone (la) and khellinone (lb) for the synthesis of new furoflavone d...

The benzoxazole derivative gelator forms a stable DMF/toluene cosolvent gel with dramatically enhanced fluorescence emission compared to its mother solution. The translucent colorless gel was changed to a solution with strong greenish fluorescence in the presence of fluoride anion with disruption of the gel structure.

Non-steroidal anti-inflammatory drugs play a major role in pain management. This article discusses the synthesis of thio-Pyrimidine, Benzoxazole, Benzothiazole and Triazole Analogues from Baylis-Hillman Bromides and their in-vitro testing for the activity of cyclooxygenase (COX) inhibition. The results are very encouraging and we can proceed for further investigations regarding their safety, in...

Novel series of triazole-benzoxazole hybrid compounds (7a-7i) have been synthesized via click chemistry between different azide derivatives and benzoxazole terminal alkynes bearing an S-methylene linkage. The starting alkyne was prepared base-catalyzed S-alkylation substrate in two-step procedures. All the intermediates final products were fully characterized by 1D NMR, IR, mass spectrometry, e...